89534-52-1Relevant academic research and scientific papers
Convenient procedure for the indium-mediated hydroxymethylation of active bromo compounds: Transformation of ketones into α-hydroxymethyl nitroalkanes
Soengas, Raquel G.,Estévez, Amalia M.
supporting information; experimental part, p. 2625 - 2627 (2010/12/18)
A very simple, safe and powerful method for the hydroxymethylation of 2-bromoesters and lactones under anhydrous conditions that avoids the use of gaseous formaldehyde is described. Moreover, under these conditions, bromonitroalkanes were converted into the corresponding α- monohydroxymethylated nitroalkanes, which are precursors of the corresponding α-amino acids. Considering the easy transformation of ketones into bromonitroalkanes, this represents a method for the formal synthesis of α-amino acids from ketones. Georg Thieme Verlag Stuttgart New York.
Recombinant Δ4,5-steroid 5 β-reductases as biocatalysts for the reduction of activated C=C-double bonds in monocyclic and acyclic molecules
Burda, Edyta,Krausser, Marina,Fischer, Gabriele,Hummel, Werner,Mueller-Uri, Frieder,Kreis, Wolfgang,Groeger, Harald
experimental part, p. 2787 - 2790 (2010/03/05)
It was found that Δ4,5-steroid 5β-reductases are capable of reducing also small molecules bearing an activated C=C double bond such as monocyclic enones and acyclic enoate esters. As preferred Δ4,5-steroid 5β-reductase (5β-StR) for this purpose, 5β-StR from Arabidopsis thaliana was used. In part, enzyme activities are even higher than that for progesterone. Successful preliminary biotransformations with enzymatic in situ cofactor recycling were also carried out. When using the prochiral compound isophorone as a substrate, a high enantioselective reaction course (>99% ee) was observed.
High catalytic activity of - for hydroformylation of olefins
Hayashi, Teruyuki,Gu, Zheng Hui,Sakakura, Toshiyasu,Tanaka, Masato
, p. 373 - 378 (2007/10/02)
Comparison of the catalytic activity of - with those of the known catalyst systems (- and Ru3(CO)12) has revealed that - is an active catalyst for hydroformylation of 1-pentene, styrene, and ethyl acrylate. - partly reduces the aldehydes initially formed into their corresponding alcohols.In the reaction of ethyl acrylate catalyzed by - or -, significant amounts of carbonylative dimers (diethyl 2-formyl-2-methylglutarate and 4-ethoxycarbonyl-4-methyl-δ-valerolactone) were also formed.
Enantioselective Reduction of 2-Methyl-3-oxopropionate by Bakers' Yeast
Nakamura, Kaoru,Miyai, Takehiko,Ushio, Kazutoshi,Oka, Shinzaburo,Ohno, Atsuyoshi
, p. 2089 - 2094 (2007/10/02)
Various esters of 2-methyl-3-oxopropionic acid were subjected to the reduction with bakers' yeast.Effects of size and bulkiness as well as hydrophobicity of alcohol moieties of the substrates on the enantioselectivity of the reduction were investigated.The substrates having bulky ester groups gave the (R)-hydroxy esters with high enantioselectivities.A mechanism to alter the stereoselectivity of the reduction is proposed.
