27772-62-9

Basic information

• Product Name: 2-FORMYLPROPIONIC ACID ETHYL ESTER
• Synonyms: ETHYL 2-FORMYLPROPIONATE;2-FORMYLPROPIONIC ACID ETHYL ESTER;2-FORMYLPROPONIC ACID ETHYL ESTER;2-FORMYLPROPIONIC ACID ETHYL ESTER 95+%;2-Formylproponic acid ethyl;2-Formylpropanoic acid ethyl ester;2-Methyl-3-oxopropionic acid ethyl ester;ethyl 2-methyl-3-oxopropanoate
• CAS NO: 27772-62-9
• Molecular Formula: C₆H₁₀O₃
• Molecular Weight: 130.14
• Mol File: 27772-62-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 159°C at 760 mmHg
• Flash Point: 53.9°C
• Appearance: /
• Density: 1,09 g/cm3
• Vapor Pressure: 2.55mmHg at 25°C
• Refractive Index: 1.408
• Storage Temp.: Freezer
• PKA: 8.15±0.29(Predicted)
• CAS DataBase Reference: 2-FORMYLPROPIONIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FORMYLPROPIONIC ACID ETHYL ESTER(27772-62-9)
• EPA Substance Registry System: 2-FORMYLPROPIONIC ACID ETHYL ESTER(27772-62-9)

Safety Data

• Statements: 10
• Safety Statements: 16
• RIDADR: 3272
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 27772-62-9(Hazardous Substances Data)

Usage

General Description

2-Formylpropionic acid ethyl ester, also known as ethyl 2-formylpropanoate, is a chemical compound with the molecular formula C6H10O3. It is a colorless liquid with a fruity odor, commonly used in the manufacturing of fragrances and flavorings. This chemical has been investigated for its potential pharmaceutical applications, including its role as an intermediate in the synthesis of pharmaceutical compounds. It is also used in organic synthesis as a building block for various chemical reactions. Additionally, it is considered to have low acute oral toxicity, making it potentially safe for use in various industrial applications with proper handling and precautions.

InChI:InChI=1/C6H10O3/c1-3-9-6(8)5(2)4-7/h4-5H,3H2,1-2H3

Upstream product

• 67-56-1 methanol 
• 759-65-9 diethyl oxalpropionate 
• 126615-15-4 2-Methyl-3-oxo-butanedioic-1-¹³C Acid Diethyl Ester 
• 201230-82-2 carbon monoxide 
• 140-88-5 ethyl acrylate 
• 7647-01-0 hydrogenchloride 
• 36056-90-3 ethyl 3,3-diethoxy-2-methylpropionate 

Downstream Products

• 89534-52-1 3-hydroxy-2-methyl-propionic acid ethyl ester 
• 64965-46-4 3-methylquinolin-4-ol 
• 13480-95-0 2-ethylthio-3,4-dihydro-5-methylpyrimidin-4-one 
• 127441-74-1 hydroxy-2' anilino-3 propenoate d'ethyle 
• 4792-54-5 ethyl pyruvate phenylhydrazone 
• 4069-67-4 7-hydroxy-3-methyl-2H-chromen-2-one 
• 54845-20-4 2-n-Buthylthiothymin 
• 20651-30-3 2-methylthio-3,4-dihydro-5-methylpyrimidin-4-one 
• 115992-51-3 cyclohexylmethyl 2-methyl-3-oxopropionate 
• 6111-99-5 ethyl diazoalaninate 
• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 
• 122009-11-4 ethyl 4-diethoxyphosphono-2-methyl-2-butenoate 
• 55514-48-2 ethyl 2-methylbut-2-enoate 

Relevant articles and documents

Binuclear Pd(I)-Pd(I) Catalysis Assisted by Iodide Ligands for Selective Hydroformylation of Alkenes and Alkynes

Since its discovery in 1938, hydroformylation has been thoroughly investigated and broadly applied in industry (>107 metric ton yearly). However, the ability to precisely control its regioselectivity with well-established Rh- or Co-catalysts has thus far proven elusive, thereby limiting access to many synthetically valuable aldehydes. Pd-catalysts represent an appealing alternative, yet their use remains sparse due to undesired side-processes. Here, we report a highly selective and exceptionally active catalyst system that is driven by a novel activation strategy and features a unique Pd(I)-Pd(I) mechanism, involving an iodide-assisted binuclear step to release the product. This method enables β-selective hydroformylation of a large range of alkenes and alkynes, including sensitive starting materials. Its utility is demonstrated in the synthesis of antiobesity drug Rimonabant and anti-HIV agent PNU-32945. In a broader context, the new mechanistic understanding enables the development of other carbonylation reactions of high importance to chemical industry.

Catalysis by water-soluble organometallic complexes in water-in-densified fluid microemulsions

A microemulsion containing water, a densified fluid, a surfactant, and an organometallic catalyst is used to catalyze chemical reactions. The organometallic catalyst preferably has substantial solubility in the water phase of the microemulsion. Separation of reaction products from the microemulsion is facilitated by removal of the densified fluid.

Excellent Regiochemical Control in the Hydroformylation of α,β-Unsaturated Esters Catalyzed by Zwitterionic Rhodium Complexes and 1,4-Bis(diphenylphosphino)butane

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