89549-75-7

Upstream product

• 613-90-1 benzoyl cyanide 
• 1122-91-4 4-bromo-benzaldehyde 
• 6048-21-1 4-bromobenzoyl cyanide 
• 100-52-7 benzaldehyde 
• 151-50-8 potassium cyanide 
• 98-88-4 benzoyl chloride 

Downstream Products

• 89549-82-6 Benzoic acid (4-bromo-phenyl)-cyano-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-methyl ester 
• 135120-41-1 5-(4-bromophenyl)-2,4-diphenyloxazole 
• 89549-65-5 4-(4-Bromo-phenyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine 
• 89549-54-2 (4-Bromo-phenyl)-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-methanone 
• 102034-65-1 2-benzoyloxy-1,2-bis(4-bromophenyl)ethanoate 

Relevant academic research and scientific papers

Synthesis of Imidazoles and Oxazoles via a Palladium-Catalyzed Decarboxylative Addition/Cyclization Reaction Sequence of Aromatic Carboxylic Acids with Functionalized Aliphatic Nitriles

We herein report an efficient approach for the assembly of multiply substituted imidazoles and oxazoles in a single-step manner. These transformations are based on a decarboxylation addition and annulation of readily accessible aromatic carboxylic acids a

Palladium-catalyzed C-H activation of simple arenes and cascade reaction with nitriles: access to 2,4,5-trisubstituted oxazoles

An efficient and straightforward protocol for the assembly of the pharmaceutically and biologically valuable oxazole skeleton is achieved for the first time from readily available simple arenes and functionalized aliphatic nitriles. This transformation in

Divergent Palladium-Catalyzed Tandem Reaction of Cyanomethyl Benzoates with Arylboronic Acids: Synthesis of Oxazoles and Isocoumarins

A palladium-catalyzed tandem reaction of cyanomethyl benzoates with arylboronic acids has been achieved. Substitution at the 2-position of cyanomethyl benzoates was found to be crucial for the selective synthesis of oxazoles and isocoumarins. Cyanomethyl

Synthesis of 2,4,5-Trisubstituted Oxazoles via Pd-Catalyzed C-H Addition to Nitriles/Cyclization Sequences

A practical and flexible intermolecular protocol for the diverse synthesis of trisubstituted oxazole derivatives via a Pd-catalyzed direct C-H addition of electronic-rich heteroarenes to O-acyl cyanohydrins bearing an α-hydrogen/cyclization sequence is described. A wide range of trisubstituted oxazoles can be prepared from readily available starting materials in good to high yields with high efficiency under redox neutral reaction conditions.

Cyanobenzoylation and hydrocyanation of aldehydes with benzoyl cyanide using no catalyst

(Matrix presented) In the presence of MS 4A in DMSO, cyanobenzoylation of various aldehydes with benzoyl cyanide proceeded very smoothly to give the corresponding cyanohydrin benzoates in high to excellent yields without an acid or a base. On the other hand, reaction of aldehydes with BzCN in DMSO-H2O also occurred readily to afford the corresponding free cyanohydrins exclusively.

CYANOHYDRINS AS SUBSTRATES IN BENZOIN CONDENSATION. REGIOCONTROLLED MIXED BENZOIN CONDENSATION

O-Benzoylated cyanohydrins of aromatic aldehydes have been used as one of the substrates in the benzoin condensation.They were treated with aromatic aldehydes under phase-transfer conditions to result in benzoin benzoates.By this method aldehydes which fail to undergo condensation using traditional conditions could be converted into benzoins.By the Umpolung of reactivity of the pertinent aldehyde it was possible to prepare both isomeric unsymmetrical benzoins, including the thermodynamically less stable ones.

Studies on Pyrazolopyrimidine Derivatives. XIII. Aryl Migration of 4-Aroyl-1H-pyrazolopyrimidines to 4-Aryl-4,5-dihydro-1H-pyrazolopyrimidine-4-carboxylic Acids

When a mixture of 4-aroyl-1-phenyl-1H-pyrazolopyrimidines (3) and sodium hydroxide in dimethyl sulfoxide (DMSO) was stirred for 1 h at room temperature, migration of the aryl group to the 4-position occurred, i.e., the benzilic acid rearrangement,