89561-22-8

Upstream product

• 19872-93-6 dimethyl 4-methoxypyridine-2,6-dicarboxylate 
• 7732-18-5 water 
• 499-51-4 Chelidamic acid 
• 19872-91-4 dimethyl 4-hydroxypyridine-2,6-dicarboxylate 
• 138-60-3 chelidamic acid 
• 5371-70-0 dimethyl 4-chloro-2,6-pyridinedicarboxylate 
• 71022-75-8 4-chloropyridine-2,6-dicarbonyl dichloride 
• 20443-03-2 4-oxo-1,4-dihydro-pyridine-2,6-dicarboxylic acid dimethyl ester 

Downstream Products

• 165590-26-1 4-methoxy-2,6-bis[(p-tolylsulfonyl)oxymethyl]pyridine 
• 170862-04-1 C₆₄H₇₈N₈O₁₀S₄ 
• 247210-94-2 [15-methoxy-3,11-bis-(toluene-4-sulfonyl)-3,7,11,17-tetraaza-bicyclo[11.3.1]heptadeca-1⁽¹⁶⁾,13⁽¹⁷⁾,14-trien-7-yl]-phosphonic acid diethyl ester 
• 170862-03-0 15-methoxy-3,11-bis-(toluene-4-sulfonyl)-3,7,11,17-tetraaza-bicyclo[11.3.1]heptadeca-1⁽¹⁶⁾,13⁽¹⁷⁾,14-triene 

Relevant academic research and scientific papers

Binding of water and solvent molecules in a 25-membered-ring host compound

The macrocyclic 15- and 25-membered-ring pyridine oligomers 1 and 2 containing three and five methoxy substituents in the 4-position of the pyridine rings were prepared by Mueller-Roescheisen cyclization and then isolated by chromatography.They are attractive as synthetic endobasic receptor molecules.X-ray structure analysis exhibits the inclusion of hydrogen-bonded solvent molecules (water and trichloromethane) inside the pentameric macrocycle 2.

RESTRUCTURING OF THE BLEOMYCIN METAL CORE. NOVEL OXYGEN-ACTIVATING LIGANDS WITH SYMMETRIZED STRUCTURE

Novel ligands having symmetrized coordination environment consisting of two histidine units and a pyridine are prepared.Oxygen activating efficiency of the iron complexes of the synthetic ligands increases by introducing electron donating substituent into the pyridine ring.

Syntheses and anti-HIV and human cluster of differentiation 4 (CD4) down-modulating potencies of pyridine-fused cyclotriazadisulfonamide (CADA) compounds

CADA compounds selectively down-modulate human cell-surface CD4 protein and are of interest as HIV entry inhibitors and as drugs for asthma, rheumatoid arthritis, diabetes and some cancers. Postulating that fusing a pyridine ring bearing hydrophobic subst

Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates

A series of tetrahydroisoquinoline-based benzodiazepine dimers were synthesized and tested for in vitro cytotoxicity against a panel of cancer cell lines. Structure-activity relationship investigation of various spacers guided by molecular modeling studie

Spectroscopic and DFT Characterization of a Highly Reactive Nonheme FeV-Oxo Intermediate

The reaction of [(PyNMe3)FeII(CF3SO3)2], 1, with excess peracetic acid at -40 °C generates a highly reactive intermediate, 2b(PAA), that has the fastest rate to date for oxidizing cyclohexane by a nonheme iron species. It exhibits an intense 490 nm chromophore associated with an S = 1/2 EPR signal having g-values at 2.07, 2.01, and 1.94. This species was shown to be in a fast equilibrium with a second S = 1/2 species, 2a(PAA), assigned to a low-spin acylperoxoiron(III) center. Unfortunately, contaminants accompanying the 2(PAA) samples prevented determination of the iron oxidation state by M?ssbauer spectroscopy. Use of MeO-PyNMe3 (an electron-enriched version of PyNMe3) and cyclohexyl peroxycarboxylic acid as oxidant affords intermediate 3b(CPCA) with a M?ssbauer isomer shift δ = -0.08 mm/s that indicates an iron(V) oxidation state. Analysis of the M?ssbauer and EPR spectra, combined with DFT studies, demonstrates that the electronic ground state of 3b(CPCA) is best described as a quantum mechanical mixture of [(MeO-PyNMe3)FeV(O)(OC(O)R)]2+ (～75%) with some FeIV(O)(?OC(O)R) and FeIII(OOC(O)R) character. DFT studies of 3b(CPCA) reveal that the unbound oxygen of the carboxylate ligand, O2, is only 2.04 ? away from the oxo group, O1, corresponding to a Wiberg bond order for the O1-O2 bond of 0.35. This unusual geometry facilitates reversible O1-O2 bond formation and cleavage and accounts for the high reactivity of the intermediate when compared to the rates of hydrogen atom transfer and oxygen atom transfer reactions of FeIII(OC(O)R) ferric acyl peroxides and FeIV(O) complexes. The interaction of O2 with O1 leads to a significant downshift of the Fe-O1 Raman frequency (815 cm-1) relative to the 903 cm-1 value predicted for the hypothetical [(MeO-PyNMe3)FeV(O)(NCMe)]3+ complex.

Electronic: Versus steric effects of pyridinophane ligands on Pd(III) complexes

Several new PdII and PdIII complexes supported by electronically and sterically tuned tetradentate pyridinophane ligands MeN4OMe, MeN4, and tBuN4 were isolated and fully characterized (MeN4OMe: N,N′-dimethyl-2,11-diaza[3,3](2,6)-para-methoxypyridinophane; MeN4: N,N′-dimethyl-2,11-diaza[3,3](2,6)pyridinophane; tBuN4: N,N′-di-tert-butyl-2,11-diaza[3,3](2,6)pyridinophane). Cyclic voltammetry studies, UV-vis and EPR spectroscopy, and X-ray crystallography were employed to reveal that the steric properties of the N-substituents of the RN4 ligands have a pronounced effect on the electronic properties of the corresponding PdIII complexes, while the electronic tuning of the ligand pyridyl groups has a surprisingly minimal effect. An explanation for these observations was provided by DFT and TD-DFT calculations which suggest that the electronic properties of the PdIII complexes are mainly dictated by their frontier molecular orbitals that have major atomic contributions from the Pd center (mainly the Pd dz2 atomic orbital) and the axial N atom donors.

A formal anti-Markovnikov hydroalkoxylation of allylic alcohols with a ruthenium catalyst

Hydroalkoxylation of C-C double bonds was achieved through the use of a ruthenium catalyst. The reaction of allylic alcohols with nucleophilic alcohols was carried out in the presence of a ruthenium catalyst prepared by RuClH(CO)(PPh3)3 and 2,6-bis(n-butyliminomethyl)-4-(piperidin-1-yl)pyridine under mild reaction conditions to afford the corresponding γ-alkoxypropanols in good yield.

The Influence of para Substituents in Bis(N-Heterocyclic Carbene) Palladium Pincer Complexes for Electrocatalytic CO2 Reduction

The effect of modifying the pyridyl para position of lutidine-linked bis(N-heterocyclic carbene) Pd pincer complexes is studied both experimentally (R = OMe, H, Br, and COOR) and computationally, showing a strong effect on the first reduction potential of the complex and allowing the reduction potential to be tuned over a wide range in relation to the Hammett σp constant of the para substituent. The effect of the pyridyl para substituent on electron density of the metal center, frontier orbital energies, and dissociation energy of the trans ligand are also investigated in the context of reactivity with CO2 through electrochemical characterization of the complexes under N2 and CO2 and controlled potential electrolysis experiments where CO2 is reduced to CO.

Synthesis of new enantiopure dimethyl- and diisobutyl -substituted pyridino-18-crown-6 ethers containing a halogen atom or a methoxy group at position 4 of the pyridine ring for enantiomeric recognition studies

New enantiomerically pure dimethyl- and diisobutyl-substituted pyridino-18-crown-6 ethers containing a halogen atom or a methoxy group at position 4 of the pyridine ring [(S,S)-1, (S,S)-2, (S,S)-3, (S,S)-4] have been synthesized. A new synthetic route and

Pyridine-based lanthanide complexes: Towards bimodal agents operating as near infrared luminescent and MRI reporters

We report two prototype Ln3+ complexes that address requirements for both MRI and luminescence imaging and we demonstrate that the presence of two H2O molecules bound to the Ln3+, beneficial for MRI applications of the Gd3+ analogue, is not a major limitation for the development of NIR luminescent agents. The Royal Society of Chemistry 2008.