89580-42-7

Basic information

• Product Name: 4-Piperidinone, 3-broMo-1-Methyl-, hydrobroMide
• Synonyms: 4-Piperidinone, 3-broMo-1-Methyl-, hydrobroMide;3-Bromo-1-methyl-4-piperidone hydrobromide
• CAS NO: 89580-42-7
• Molecular Formula: BrH*C₆H₁₀BrNO
• Molecular Weight: 272.96564
• Mol File: 89580-42-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 120-122℃
• Appearance: /
• CAS DataBase Reference: 4-Piperidinone, 3-broMo-1-Methyl-, hydrobroMide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Piperidinone, 3-broMo-1-Methyl-, hydrobroMide(89580-42-7)
• EPA Substance Registry System: 4-Piperidinone, 3-broMo-1-Methyl-, hydrobroMide(89580-42-7)

Safety Data

• Hazardous Substances Data: 89580-42-7(Hazardous Substances Data)

Usage

General Description

4-Piperidinone, 3-bromo-1-methyl-, hydrobromide is a chemical compound that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is a derivative of piperidinone, a heterocyclic compound with a six-membered ring containing one nitrogen atom. The presence of the bromo and methyl groups in the structure of this compound make it a valuable building block for the synthesis of various organic compounds. Its hydrobromide form is a salt of the compound, which is often used for easier handling and storage. This chemical has applications in the pharmaceutical and agrochemical industries, and its properties make it useful for the development of new drugs and agricultural products.

Upstream product

• 1445-73-4 1-Methyl-4-piperidone 

Downstream Products

• 143150-92-9 2-Bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]-pyridine 
• 720720-96-7 5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloric acid salt 
• 480449-70-5 edoxaban 
• 480449-71-6 [14C]-Edoxaban tosylate 

Relevant articles and documents

Method for preparing edoxaban from trichloroacetophenone onium salt derivatives

The invention provides a method for preparing edoxaban by using 2, 2, 2-trichloro-1-(4, 5, 6, 7-tetrahydro-5-methylthiazolo[5, 4-c]pyridinium-1-yl) ethanone chloride. The preparation method comprisesthe following steps: preparing 2, 2, 2-trichloro-1-(4, 5, 6, 7-tetrahydro-5-methylthiazolo[5, 4-c]pyridinium-1-yl) ethanone chloride, namely 109C5-11; the invention discloses a preparation method of N1[(1S, 2R, 4S)-2-amino-4-[(dimethylamino) carbonyl]cyclohexyl]-N2(5-chloro-2-pyridyl) oxalamide dimesylate, namely 109T2-31. The 109C5-11 is used as an acylation reagent to prepare the edoxaban with 109T2-31. The preparation method comprises the following steps: preparing the edoxaban by using the 109C5-11 as the acylation reagent; the novel method overcomes the defect that expensive condensing agents EDCI.HCl and activating agents HOBt need to be used in the prior art. The new method provided by the invention is beneficial to more economically and more efficiently realizing industrial scale production of the Edoxaban p-toluenesulfonate hydrate.