89637-63-8Relevant articles and documents
Geranyl acetone pyrophosphate intermediate preparation method
-
Paragraph 0039, (2018/07/30)
The invention provides a geranyl acetone pyrophosphate intermediate preparation method, which comprises: carrying out hydroxyl protection on farnesol as a raw material, preparing an epoxy intermediate, carrying out epoxy cutting to obtain an aldehyde, carrying out a reaction with a methyl Grignard reagent, oxidizing the hydroxyl, deprotecting to obtain (5E,9E)-11-hydroxy-5,9-dimethylundeca-5,9-dien-2-one 7, carrying out hydroxyl halogenations, and carrying out a reaction with a pyrophosphate to obtain the geranyl acetone pyrophosphate. According to the present invention, the method has advantages of low cost, mild reaction conditions and less isomer impurities, and is suitable for scale-up production.
METHOD FOR PRODUCING BISABOLOL WHICH IS FARNESOL FREE OR IS LOW IN FARNESOL
-
Page/Page column 7-8, (2010/09/07)
The present invention relates to a method of producing pure or enriched bisabolol by separating substance mixtures comprising bisabolol and farnesol by selective esterification of farnesol and subsequent distillative separation. The invention relates specifically to a method as specified above comprising the selective transesterification of mixtures comprising formyl-bisabolol and formyl-farnesol and subsequent distillative separation. The present invention furthermore relates to a method of producing farnesol esters.