89637-63-8Relevant academic research and scientific papers
Geranyl acetone pyrophosphate intermediate preparation method
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Paragraph 0039, (2018/07/30)
The invention provides a geranyl acetone pyrophosphate intermediate preparation method, which comprises: carrying out hydroxyl protection on farnesol as a raw material, preparing an epoxy intermediate, carrying out epoxy cutting to obtain an aldehyde, carrying out a reaction with a methyl Grignard reagent, oxidizing the hydroxyl, deprotecting to obtain (5E,9E)-11-hydroxy-5,9-dimethylundeca-5,9-dien-2-one 7, carrying out hydroxyl halogenations, and carrying out a reaction with a pyrophosphate to obtain the geranyl acetone pyrophosphate. According to the present invention, the method has advantages of low cost, mild reaction conditions and less isomer impurities, and is suitable for scale-up production.
Highly Active Manganese-Mediated Acylation of Alcohols with Acid Chlorides or Anhydrides
Joo, Seong-Ryu,Youn, Young-Jin,Hwang, Young-Ran,Kim, Seung-Hoi
, p. 2665 - 2669 (2017/10/07)
To explore further the practical uses of highly active manganese (Mn?), a variety of alcohols were treated with Mn?, and the resulting complexes were coupled with acid chlorides and/or acetic anhydride in the absence of any extra catalyst. The subsequent reactions took place smoothly under mild conditions, providing the corresponding O-acylation products in good to excellent isolated yields.
METHOD FOR PRODUCING BISABOLOL WHICH IS FARNESOL FREE OR IS LOW IN FARNESOL
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Page/Page column 7-8, (2010/09/07)
The present invention relates to a method of producing pure or enriched bisabolol by separating substance mixtures comprising bisabolol and farnesol by selective esterification of farnesol and subsequent distillative separation. The invention relates specifically to a method as specified above comprising the selective transesterification of mixtures comprising formyl-bisabolol and formyl-farnesol and subsequent distillative separation. The present invention furthermore relates to a method of producing farnesol esters.
PROCESS FOR REMOVING FARNESOL FROM MIXTURES WITH ALPHA-BISABOLOL
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Page/Page column 5-6, (2008/06/13)
Process for esterification of farnesol in an initial mixture comprising alpha-bisabolol, farnesol and optionally other components, with the following steps: 1. Preparation or production of the initial mixture, 2. Adding (i) a transesterification catalyst and (ii) one or more compounds of formula (B) [in-line-formulae]R2YnCO2R1??(B) [/in-line-formulae] in which the following applies: R1 stands for an alkyl residue with 1 to 12 C atoms; R2 stands for hydrogen, an alkyl residue with 1 to 20 C atoms, a cycloalkyl residue with 5 to 20 C atoms, an aryl residue with 6 to 20 C atoms or a heteroaryl residue with 5 to 20 C atoms; and Y stands for CH2, CH(Me), CH(Et), C(Me)2, CH2—CH(Me), CH(Me)-CH2 or CH2—CH(Me)-CH2 and n stands for a whole number from 0 to 6; or R2 stands for a group CO2R3, R3 standing for an alkyl residue with 1 to 12 C atoms; and Y stands for CH2, CH(Me), CH(Et), C(Me)2, CH2—CH(Me), CH(Me)-CH2 or CH2—CH(Me)-CH2 and n stands for a whole number from 0 to 8, or Y stands for an optionally substituted phenyl or naphthyl ring with a total of at most four substituents on the ring, n=1 applying.
