89637-68-3Relevant academic research and scientific papers
Geranyl acetone pyrophosphate intermediate preparation method
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Paragraph 0039; 0040; 0041, (2018/07/30)
The invention provides a geranyl acetone pyrophosphate intermediate preparation method, which comprises: carrying out hydroxyl protection on farnesol as a raw material, preparing an epoxy intermediate, carrying out epoxy cutting to obtain an aldehyde, carrying out a reaction with a methyl Grignard reagent, oxidizing the hydroxyl, deprotecting to obtain (5E,9E)-11-hydroxy-5,9-dimethylundeca-5,9-dien-2-one 7, carrying out hydroxyl halogenations, and carrying out a reaction with a pyrophosphate to obtain the geranyl acetone pyrophosphate. According to the present invention, the method has advantages of low cost, mild reaction conditions and less isomer impurities, and is suitable for scale-up production.
Stereo- and regioselective synthesis of squalene tetraepoxide
Tong, Rongbiao,Boone, Matthew A.,McDonald, Frank E.
scheme or table, p. 8407 - 8409 (2010/02/17)
(Chemical Equation Presented) Squalene tetraepoxide, a putative biosynthetic precursor to a variety of oxacyclic triterpenoid natural products, has been efficiently synthesized by anionic coupling of two farnesol-derived diepoxides, which have arisen from
