89694-55-3

Usage

Uses

Used in Organic Synthesis:
5-Bromo-4,6-dimethylpyridin-2-ol is used as a key intermediate in organic synthesis for the production of various chemical compounds. Its unique structure allows for versatile reactions and modifications, facilitating the creation of a wide range of organic molecules.
Used in Pharmaceutical Production:
As a building block in pharmaceuticals, 5-Bromo-4,6-dimethylpyridin-2-ol is utilized in the development of new drugs. Its presence in the molecular structure can influence the pharmacological properties of the final product, making it a valuable component in medicinal chemistry.
Used in Agrochemical Development:
5-broMo-4,6-diMethylpyridin-2-ol also serves as a precursor in the creation of agrochemicals, contributing to the development of new pesticides, herbicides, and other agricultural products that can improve crop yields and protect against pests.
Used in Research and Development:
5-Bromo-4,6-dimethylpyridin-2-ol is employed as a research tool in organic chemistry, where its unique properties and reactivity are studied to advance understanding in the field and to develop new synthetic methods and applications.
Used in Medicinal Property Exploration:
5-broMo-4,6-diMethylpyridin-2-ol has been studied for its biological activities and potential medicinal properties, making it a candidate for further research into its therapeutic applications and effects on various biological systems.

Upstream product

• 89856-44-0 2-amino-5-bromo-4,6-dimethylpyridine 
• 23819-87-6 5-bromo-2-hydroxy-4,6-dimethyl-nicotinonitrile 
• 5407-87-4 2-Amino-4,6-dimethylpyridine 
• 99314-62-2 ethyl-5-bromo-4,6-dimethyl-2(1H)-pyridone-3-carboxylate 
• 5407-88-5 N-(4,6-dimethyl-2-pyridinyl)acetamide 
• 99179-94-9 N-(5-bromo-4,6-dimethyl-[2]pyridyl)-acetamide 

Downstream Products

• 627098-09-3 6-methoxy-2,4-dimethylpyridin-3-ol 
• 819069-57-3 3-bromo-6-methoxy-2,4-dimethylpyridine 
• 1429511-23-8 ethyl 5-(2,5-difluoro-4-(6-methoxy-2,4-dimethylpyridin-3-yl)phenyl)-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate 
• 1429511-39-6 ethyl 5-[4-(6-ethoxy-2,4-dimethylpyridin-3-yl)-2-nitrophenyl]-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate 
• 1429511-14-7 ethyl 5-[4-(6-isopropyloxy-2,4-dimethylpyridin-3-yl)-2-nitrophenyl]-1-[(S)-tetrahydrofuran-3-yl]-1H-pyrazole-4-carboxylate 
• 1429510-95-1 5-(2,4-dimethoxybenzyl)-7-(2-methoxy-4,6-dimethylpyridin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[4,3-c]quinolin-4(5H)-one 
• 1429510-55-3 (6-methoxy-2,4-dimethylpyridin-3-yl)boronic acid 

Relevant academic research and scientific papers

PYRIDINYLPYRAZOLOQUINOLINE COMPOUND

A compound represented by formula (I), or a pharmaceutically acceptable salt thereof: wherein R1 represents a group represented by the formula: a group represented by the formula: or a group represented by the formula: and R2 represe

PYRAZOLOPYRIDINE PYRAZOLOPYRIMIDINE AND RELATED COMPOUNDS

In one aspect this invention relates generally to compounds of Formula: and sub-formulas thereof, or a tautomer of each thereof, a pharmaceutically acceptable salt of each thereof, or a pharmaceutically acceptable solvate of each of the foregoing, where X1, L1, L3, and R3 are described herein.

PYRAZOLOQUINOLINE DERIVATIVES

A compound and/or pharmacologically acceptable salt thereof represented by the formula (I) has PDE9 inhibitory action, so that the intracerebral cGMP concentration is anticipated to be elevated. The PDE9 inhibitory action and the increase in cGMP lead to the improvement of learning and memory behaviors, and the compound (I) has applicability as a therapeutic agent for cognitive dysfunctions in Alzheimer's disease. wherein R1 is a hydrogen atom; R2 is an aromatic ring group, etc.; R3 is a hydrogen atom, etc; R4 is a hydrogen atom; R5 is an oxepanyl group, etc.; R6 is a hydrogen atom.

INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS

The present invention relates to compounds defined by formula (I) wherein the variables R1, R2, R3, m, and n are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are activato

INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS

The present invention relates to compounds defined by formula (I) wherein the variables R1, R2, R3, m, and n are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are activators of the receptor GPR40 and thus are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

Synthesis and reactivity of some 6-substituted-2,4-dimethyl-3-pyridinols, a novel class of chain-breaking antioxidants

The synthesis and study of a series of 6-substituted-2,4-dimethyl-3- pyridinols having interesting antioxidant properties is reported. The general synthetic strategy leading to the compounds involved a low-temperature aryl bromide-to-alcohol conversion as the last step. 2,4-Dimethyl-3-pyridinol (1a), 2,4,6-trimethyl-3-pyridinol (1b), and 2,4-dimethyl-6-(dimethylamino)-3-pyridinol (1d) were thus prepared from the corresponding 3-bromopyridine precursor. The methoxy derivative 2,4-dimethyl-6-(methoxy)-3-pyridinol (1c) was also prepared by an alternate route via a Baeyer-Villiger reaction on the substituted benzaldehyde precursor. Novel bicyclic pyridinols 2 and 3 required prior construction of the ring structure. Thus, 2 was prepared by the use of a 6-step intramolecular Friedel-Crafts strategy, and 3 required an 11-step sequence with a thermolytic intramolecular inverse-demand Diels-Alder reaction between a pyrimidine ring and an alkyne as the key step. Basicities of the pyridinols approached physiological pH with increasing electron density in the ring. Pyridinols 1a-d were found to be indefinitely stable to air oxidation while 2 and 3 decomposed upon extended exposure to the atmosphere. The reactivities of the pyridinols toward chain-carrying peroxyl radicals in homogeneous organic solution were examined by studying the kinetics of radical-initiated styrene autoxidations under controlled conditions. These experiments revealed that some of the newly synthesized pyridinols are the most effective phenolic chain-breaking antioxidants reported to date.

Novel Nucleophilic Substitution of Alkyl Bromo-2(1H)-pyridones

Nucleophilic substitution of certain alkyl bromo-2(1H)-pyridones gave some unexpected products where the alkyl group is substituted and the ring bromine is replaced by hydrogen.The expected ring substituted product is also formed, but only as the minor pr