89791-47-9

Basic information

• Product Name: 2-Methyl-tetrahydro-pyran-4-ol
• Synonyms: 2-Methyl-tetrahydro-pyran-4-ol;2-Methyltetrahydro-2H-pyran-4-ol;2-methyloxan-4-ol;2H-Pyran-4-ol, tetrahydro-2-methyl-
• CAS NO: 89791-47-9
• Molecular Formula: C₆H₁₂O₂
• Molecular Weight: 116
• Mol File: 89791-47-9.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 210℃
• Flash Point: 92℃
• Appearance: /
• Density: 1.014
• Vapor Pressure: 0.044mmHg at 25°C
• Refractive Index: 1.453
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Methyl-tetrahydro-pyran-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-tetrahydro-pyran-4-ol(89791-47-9)
• EPA Substance Registry System: 2-Methyl-tetrahydro-pyran-4-ol(89791-47-9)

Safety Data

• RIDADR: UN1993
• Hazardous Substances Data: 89791-47-9(Hazardous Substances Data)

Usage

General Description

2-Methyl-tetrahydro-pyran-4-ol, also known as 2-Methyl-4-hydroxytetrahydropyran, is a chemical compound with a molecular formula of C6H12O2. It is a colorless liquid with a fruity odor and is commonly used as a flavoring agent in the food and beverage industry. It is also used in the production of perfumes and as a solvent in various industries. 2-Methyl-tetrahydro-pyran-4-ol is considered to be relatively safe for human consumption and is not associated with any known health hazards. However, it should be handled and stored with care due to its flammability and potential for irritation to the skin and eyes.

InChI:InChI=1/C6H12O2/c1-5-4-6(7)2-3-8-5/h5-7H,2-4H2,1H3

Upstream product

• 121077-78-9 2-[((E)-2-Propenyl)-[1,3]dithian-2-yl]-ethanol 
• 627-27-0 homoalylic alcohol 
• 123-63-7 paracetaldehyde 
• 75-07-0 acetaldehyde 
• 1193-20-0 2-methyltetrahydro-4H-pyran-4-one 
• 33747-08-9 cis-2-methyltetrahydro-2H-pyran-4-ol 
• 10299-30-6 hexane-1,2,5-triol 

Downstream Products

• 10141-72-7 2-methyloxane 
• 1193-20-0 2-methyltetrahydro-4H-pyran-4-one 
• 55230-39-2 4-nitro-benzoic acid-(2-methyl-tetrahydro-pyran-4-yl ester) 
• 33747-08-9 (2R,4R)-2-methyltetrahydro-2H-pyran-4-ol 
• 75-07-0 acetaldehyde 
• 82110-13-2 (2S,4S)-4-hydroxy-2-methyl-3,4,5,6-tetrahydro-2H-pyran 

Relevant articles and documents

Ketoreductase/Transaminase, One-Pot, Multikilogram Biocatalytic Cascade Reaction

A biocatalytic cascade to produce tert-butyl ((2R,4R)-2-methyltetrahydro-2H-pyran-4-yl)carbamate 6 has been demonstrated at the multikilogram scale. In this reaction, a racemic ketone is resolved by reducing the undesired ketone using a ketone reductase (KRED). The reduction is stereospecific for the 2-position of substrate (2S)-ketone leaving the (2R)-ketone unreacted. After the (2S)-ketone has been depleted, a transaminase is added to catalyze the enantioselective transamination of the ketone, resulting in formation of the (2R, 4R)-amine 6. The product is recovered from the aqueous reaction after Boc protection.

NOVEL IMIDAZO[4,5-C]QUINOLINE DERIVATIVES AS LRRK2 INHIBITORS

The present invention provides novel imidazo[4,5-c]quinoline derivatives of Formula (I), and the pharmaceutically acceptable salts thereof I wherein R1, R2 and R3 are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of Formula I and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy.

SYNTHESIS OF R-GLUCOSIDES, SUGAR ALCOHOLS, REDUCED SUGAR ALCOHOLS, AND FURAN DERIVATIVES OF REDUCED SUGAR ALCOHOLS

Disclosed herein are methods for synthesizing 1,2,5,6-hexanetetrol (HTO), 1,6 hexanediol (HDO) and other reduced polyols from C5 and C6 sugar alcohols or R glycosides. The methods include contacting the sugar alcohol or R-glycoside with a copper catalyst, most desirably a Raney copper catalyst with hydrogen for a time, temperature and pressure sufficient to form reduced polyols having 2 to 3 fewer hydoxy groups than the starting material. When the starting compound is a C6 sugar alcohol such as sorbitol or R-glycoside of a C6 sugar such as methyl glucoside, the predominant product is HTO. The same catalyst can be used to further reduce the HTO to HDO.