89804-66-0

Basic information

• Product Name: 1,2,4-Oxadiazole, 3-phenyl-5-[4-(trifluoromethyl)phenyl]-
• CAS NO: 89804-66-0
• Molecular Formula: C15H9F3N2O
• Molecular Weight: 290.244
• Mol File: 89804-66-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1,2,4-Oxadiazole, 3-phenyl-5-[4-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Oxadiazole, 3-phenyl-5-[4-(trifluoromethyl)phenyl]-(89804-66-0)
• EPA Substance Registry System: 1,2,4-Oxadiazole, 3-phenyl-5-[4-(trifluoromethyl)phenyl]-(89804-66-0)

Safety Data

• Hazardous Substances Data: 89804-66-0(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 932-90-1 Benzaldoxime 
• 698-16-8 benzohydroximoyl chloride 
• 613-92-3 N-hydroxyl-benzamidine 
• 613-92-3 N-hydroxybenzenecarboximidamide 
• 100-47-0 benzonitrile 
• 3300-51-4 p-Trifluoromethylbenzylamine 
• 6140-17-6 4-methylbenzotrifluoride 
• 1670-14-0 benzamidine monohydrochloride 
• 2227-79-4 benzenecarbothioamide 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 2967-66-0 methyl 4-(trifluoromethyl)benzoate 

Relevant articles and documents

Electrochemical synthesis of 1,2,4-oxadiazoles from amidoximes through dehydrogenative cyclization

A convenient and efficient method for the generation of the iminoxy radical through anodic oxidation was developed for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles fromN-benzyl amidoximes. The transformation proceeds through 1.5-Hydrogen Atom Transfer (1,5-HAT) and intramolecular cyclization. The process features simple operation, mild conditions, broad substrate scope and high functional group compatibility, and provides a facile and practical way for the preparation of 1,2,4-oxadiazoles.

Facile room-temperature assembly of the 1,2,4-oxadiazole core from readily available amidoximes and carboxylic acids

A one-pot ambient-temperature procedure for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles from amidoximes and carboxylic acids under superbase-promoted conditions is reported.

Synthesis of 1,2,4-Oxadiazoles via DDQ-Mediated Oxidative Cyclization of Amidoximes

An oxidative cyclization of amidoximes to form 1,2,4-oxadiazoles, mediated by 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), is described. A range of alkyl, aryl, and heteroaryl substrates are tolerated under these conditions. This reaction serves as an alternate approach for the synthesis of functionally diverse oxadiazoles via a rapid and straightforward synthetic procedure.