89873-65-4

Upstream product

• 109-06-8 α-picoline 
• 2654-66-2 1-Benzyl-6-methylpyridinium bromide 
• 89873-52-9 1-Benzyl-6-methyl-1,2,5,6-tetrahydropyridine N-oxide 
• 89873-78-9 1-Benzyl-6-methyl-1,2,5,6-tetrahydropyridine 
• 100-39-0 benzyl bromide 
• 84268-83-7 1-Benzyl-2-cyano-6-methyl-3-piperideine 

Downstream Products

• 84268-80-4 (2R,6S)-1-Benzyl-6-methyl-2-propyl-piperidine-2-carbonitrile 
• 89873-66-5 cis-1-Benzyl-2-cyano-6-methylpiperidine 
• 84268-78-0 (2S,6R)-1-Benzyl-2-methyl-6-undecyl-piperidine 
• 84268-78-0 1-Benzylsolenopsin A 
• 84268-81-5 (2S,6R)-1-Benzyl-2-methyl-6-propyl-piperidine 
• 84268-81-5 rac-epi-dihydropinidine 
• 63950-16-3 cis-6-methyl-2-undecanylpiperidine 
• 28720-60-7 solenopsin A 

Relevant academic research and scientific papers

2-Cyano-Δ3-piperideines. 12. Stereochemistry of Formation of N-Benzyl-2-cyano-Δ3-piperideines and Facile Isomerization on Alumina to 2-Cyano-Δ4-piperideines. A Potentially General Route to the Synthesis of 2,6-Disubstitute

The reaction of the piperideine N-oxides 1a-f with trifluoroacetic anhydride in CH2Cl2 at 0 deg C (Polonovski-Potier reaction) led to the formation of the N-benzyl-2-cyano-Δ3-piperideines 3a-f.Epimeric mixtures were obtained for the amino nitri

2-CYANO Δ3 PIPERIDINES VI: A GENERAL METHOD FOR THE STEREOSELECTIVE SYNTHESIS OF CIS AND TRANS 2,6-DIALKYLPIPERIDINE ALKALOIDS

The cis 2,6-dialkylpiperidine alkaloid (+/-) dihydro-pinidine 7b and the trans alkaloid (+/-) solenopsin A 5a were synthesized from a common α-aminonitrile synthon 1.The key step in this synthesis was the stereoselective reductive decyanation of the 1-benzyl-2-cyano-2',6-dialkylpiperidines 3a and 3b.