898776-32-4

Usage

InChI:InChI=1/C18H18ClNO/c19-17-5-3-4-16(12-17)18(21)15-8-6-14(7-9-15)13-20-10-1-2-11-20/h3-9,12H,1-2,10-11,13H2

Upstream product

• 123-75-1 pyrrolidine 
• 945657-22-7 (4-bromomethyl-phenyl)(3-chloro-phenyl)methanone 
• 106-38-7 para-bromotoluene 
• 587-04-2 m-Chlorobenzaldehyde 
• 13395-60-3 (3-chlorophenyl)(4-methylphenyl)methanone 

Downstream Products

• 927690-10-6 (+/-)-(3-chlorophenyl)[4-(pyrrolidin-1-ylmethyl)phenyl]phenylmethanol 
• 927690-07-1 (+/-)-(3-chlorophenyl)[4-(pyrrolidin-1-ylmethyl)phenyl]methanol 
• 946005-76-1 1-{4-[chloro-(3-chloro-phenyl)-methyl]-benzyl}-pyrrolidine 
• 1050527-75-7 (+/-)-1-(3-chlorophenyl)-1-[4-(pyrrolidin-1-ylmethyl)phenyl]methylamine 
• 1050526-88-9 (+/-)-7-chloro-N-{(3-chlorophenyl)[4-(pyrrolidin-1-ylmethyl)phenyl]methyl}-4-aminoquinoline 

Relevant academic research and scientific papers

NOVEL 4-AMINO-QUINOLINE DERIVATIVES USEFUL AS ANTI-MALARIA DRUGS

The present invention relates to clotrimazole/quinoline hybrids useful as active ingredients of anti-malaria drugs. The compounds show a remarkable in vitro biological activity especially against the chloroquine-resistant Plasmodium falciparum strains and

NOVEL 4-AMINO-QUINOLINE DERIVATIVES USEFUL AS ANTI-MALARIA DRUGS

The present invention relates to clotrimazole/quinoline hybrids useful as active ingredients of anti-malaria drugs. The compounds show a remarkable in vitro biological activity especially against the chloroquine-resistant Plasmodium falciparum strains and

Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling

The design, synthesis, and antiplasmodial activity of antimalarial heterodimers based on the 1,4-bis(3-aminopropyl)piperazine linker is reported. In this series key structural elements derived from quinoline antimalarials were coupled to fragments capable

ANTIMALARIAL AGENTS HAVING POLYAROMATIC STRUCTURE

Antimalarial agents having a novel pharmacophore of formula (I) are herein described. These polycyclic compounds are able to inhibit chloroquine-sensitive and chloroquine-resistant strains ofPlasmodium falciparum (Pf). Furthermore, the synthesis of these compounds involves few steps from commercial products with low cost of production.Λa présente invention concerne des agents antimalariaux comportant un nouveau pharmacophore de formule (I). Ces composés polycycliques sont susceptibles d''inhiber les souches sensibles à la chloroquine et résistantes à la chloroquine de Plasmodium falciparum (Pf). En outre, la synthèse de ces composés est peu onéreuse et implique peu d''étapes à partir des produits commerciaux.

Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: Exploring an innovative pharmacophore

Identification of new molecular scaffolds structurally unrelated to known antimalarials may represent a valid strategy to overcome resistance of P. falciparum (Pf) to currently available drugs. We describe herein the investigation of a new polycyclic phar