898776-54-0Relevant academic research and scientific papers
Inorganic alkali catalytic 1, 5 - ketonic ester apperception compound synthesis method
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Paragraph 0051-0053, (2017/10/11)
The invention discloses a synthesis method for a 1,5-ketonic ester compound under catalyzing of inorganic base. The synthesis method comprises the following steps: taking a compound of the general formula I as a raw material, taking inorganic base as a ca
Sequential Michael addition/retro-Claisen condensation of aromatic β-diketones with α,β-unsaturated esters: An approach to obtain 1,5-ketoesters
Cai, Gui-Xin,Wen, Jing,Lai, Ting-Ting,Xie, Dan,Zhou, Cheng-He
supporting information, p. 2390 - 2394 (2016/03/01)
A K2CO3-catalyzed one-pot protocol involving sequential C-C bond formation and cleavage of aromatic β-diketones with α,β-unsaturated esters is developed to obtain 1,5-ketoesters. The sequential reaction via Michael addition and retro-Claisen condensation proceeds smoothly under mild conditions in up to 98% isolated yield. The mechanism study disclosed that the cascade process involved C-C bond cleavage of aromatic β-diketone as a phenacyl donor under alcoholic alkalescent conditions.
Catalytic asymmetric hydrogenation of δ-ketoesters: Highly efficient approach to chiral 1,5-diols
Yang, Xiao-Hui,Xie, Jian-Hua,Liu, Wei-Peng,Zhou, Qi-Lin
, p. 7833 - 7836 (2013/08/23)
High turnover: An highly efficient catalytic asymmetric hydrogenation of δ-aryl-δ-ketoesters has been realized by using the chiral spiroiridium catalyst (R)-1. Chiral 1,5-diol products are obtained with excellent enantioselectivity and turnover numbers (TONs) as high as 100 000. TOF=turnover frequency. Copyright
A series of thiazole derivatives bearing thiazolidin-4-one as non-competitive ADAMTS-5 (aggrecanase-2) inhibitors
Atobe, Masakazu,Maekawara, Naomi,Ishiguro, Noriko,Sogame, Shinya,Suenaga, Yoshihito,Kawanishi, Masashi,Suzuki, Hiroko,Jinno, Norimasa,Tanaka, Eiichi,Miyoshi, Shiro
, p. 2106 - 2110 (2013/04/24)
A series of thiazole bearing thiazolidin-4-one was discovered via high-throughput screening as non-competitive inhibitors of ADAMTS-5. Compound 31 appeared to give the best ADAMTS-5 inhibition and good selectivity over other metalloproteases.
