89937-77-9

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its role in the production process is crucial, as it aids in the creation of new and effective medications.
Used in Agrochemical Industry:
Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate is also utilized as a chemical intermediate in the agrochemical sector. It contributes to the development of new agrochemical products, such as pesticides and herbicides, which are essential for agricultural productivity and crop protection.

InChI:InChI=1/C7H7NO3/c1-11-7(10)5-2-3-8-6(9)4-5/h2-4H,1H3,(H,8,9)

Upstream product

• 67-56-1 methanol 
• 22282-72-0 2-hydroxyisonicotinic acid 
• 6313-54-8 2-chloroisonicotinic acid, 
• 6937-03-7 methyl 2-aminoisonicotinate 
• 13362-28-2 2-aminoisonicotinic acid 
• 22282-72-0 2-oxo-1,2-dihydropyridine-4-carboxylic acid 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 1160938-15-7 methyl 2-(acetyloxy)-4-pyridinecarboxylate 
• 105596-63-2 2-methoxy-isonicotinic acid 
• 3783-38-8 methyl isonicotinate N-oxide 

Downstream Products

• 98140-91-1 2-hydroxy-isonicotinic acid hydrazide 
• 1159599-62-8 2-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-isonicotinic acid methyl ester 
• 1203544-02-8 1-isopropyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid 
• 1346498-58-5 methyl 1-isopropyl-2-oxo-1,2-dihydropyridine-4-carboxylate 
• 127838-58-8 4-(hydroxymethyl)pyridin-2(1H)-one 
• 1245425-94-8 methyl 1-(4-methoxy-3-methylphenyl)-2-oxo-1,2-dihydropyridine-4-carboxylate 
• 1245425-86-8 methyl 1-(3-methoxy-4-((2-(trimethylsilyl)ethoxy)methoxy)phenyl)-2-oxo-1,2-dihydropyridine-4-carboxylate 
• 1570496-11-5 4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-1-yl)methyl)pyridin-2(1H)-one 
• 1570496-12-6 4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-1,2,4-triazol-1-yl)methyl]-1-(2-methylpropyl)-1,2-dihydropyridin-2-one 
• 1570496-14-8 5-(1-((2-isobutoxypyridin-4-yl)methyl)-5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole 
• 92199-59-2 ethyl 2-phenylpyridine-4-carboxylate 
• 25504-47-6 methyl (RS)-2-oxopiperidine-4-carboxylate 
• 74470-33-0 methoxycarbonyl-4 thiocarbonyl-2 dihydropyridine 
• 1072880-94-4 2-cyclohexylcarbamoyloxy-isonicotinic acid methyl ester 

Relevant academic research and scientific papers

Synthesis and biological evaluation of a series of novel pyridinecarboxamides as potential multi-receptor antipsychotic drugs

In previous study, a series of benzamides was identified as potent antipsychotic agents. As a continuation of the program to discover novel antipsychotics, herein we reported the evaluation of a series of pyridinecarboxamide derivatives. The most promising compound 7h not only held good activities on dopamine D2, serotonin 5-HT1A and 5-HT2A receptors, but also exhibited low potency for α1A, H1 and 5-HT2C receptors, indicating a low propensity of side effects like orthostatic hypotension and weight gain. Furthermore, 7h exhibited more potent antipsychotic-like effect than aripiprazole in behavioral studies. The preliminary results were promising enough for further research around this scaffold.

MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

cGAS ANTAGONIST COMPOUNDS

Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

3- HETEROARYL SUBSTITUTED 5-TRIFLUOROMETHYL OXADIAZOLES AS HISTONE DEACETYLASE 6 (HDAC6) INHIBITORS

The present invention is directed to substituted 5-trifluoromethyl oxadiazole compounds of generic formula (I) (I) or a pharmaceutically acceptable salt thereof. In particular, the invention is directed to a class of heteroaryl substituted 5-trifluoromethyl oxadiazole compounds of formula I which may be useful as HDAC6 inhibitors for treating cellular proliferative diseases, including cancer, neurodegenerative diseases, such as schizophrenia and stroke, as well as other diseases.

TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE

Provided are quinoline carboxamide and quinoline carbonitrile compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1, R 2, L, X 1, X 2, and X 3, are as defined herein. The compounds of the invention, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising them, are useful as non-competitive mGluR2 antagonists, or mGluR2 negative allosteric modulators (NAMs), and may be useful in methods of treating a person in need thereof for diseases or disorders in which the mGluR2-NAM receptor plays a causative role, such as Alzheimer's disease, cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders.

Discovery, design, and synthesis of indole-based EZH2 inhibitors

The discovery and optimization of a series of small molecule EZH2 inhibitors is described. Starting from dimethylpyridone HTS hit (2), a series of indole-based EZH2 inhibitors were identified. Biochemical potency and microsomal stability were optimized during these studies and afforded compound 22. This compound demonstrates nanomolar levels of biochemical potency (IC50 = 0.002 μM), cellular potency (EC50 = 0.080 μM), and afforded tumor regression when dosed (200 mpk SC BID) in an EZH2 dependent tumor xenograft model.

MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

Modulators of methyl modifying enzymes, compositions and uses thereof

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.

MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein