89960-36-1

Basic information

• Product Name: 1-BENZYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLIC ACID
• Synonyms: 1-BENZYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLIC ACID
• CAS NO: 89960-36-1
• Molecular Formula: C₁₃H₁₁NO₃
• Molecular Weight: 229.23
• Mol File: 89960-36-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 133,5-134,5°C
• Boiling Point: 472.8°C at 760 mmHg
• Flash Point: 239.8°C
• Appearance: /
• Density: 1.355g/cm³
• Vapor Pressure: 9.57E-10mmHg at 25°C
• Refractive Index: 1.643
• CAS DataBase Reference: 1-BENZYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLIC ACID(89960-36-1)
• EPA Substance Registry System: 1-BENZYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLIC ACID(89960-36-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 89960-36-1(Hazardous Substances Data)

Usage

General Description

1-BENZYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLIC ACID, also known as benzoyl nicotinic acid, is a chemical compound with a molecular formula C16H15NO3. It is a derivative of nicotinic acid, a form of vitamin B3. 1-BENZYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLIC ACID is used in the pharmaceutical industry for its potential therapeutic properties, such as its ability to act as an anti-inflammatory and antioxidant agent. It also has potential applications in the field of cosmetics and skincare due to its beneficial effects on the skin. Additionally, it has been studied for its potential use in the treatment of certain medical conditions, such as neurodegenerative diseases and diabetes.

InChI:InChI=1/C13H11NO3/c15-12-11(13(16)17)7-4-8-14(12)9-10-5-2-1-3-6-10/h1-8H,9H2,(H,16,17)

Upstream product

• 609-71-2 2-hydroxy-3-carboxypyridine 
• 100-39-0 benzyl bromide 
• 2942-59-8 2-chloronicotinic acid 
• 400082-66-8 methyl 1-benzyl-2-oxo-1,2-dihydropyridine-3-carboxylate 

Downstream Products

• 1753-62-4 N-benzyl-2-pyridone 
• 1037082-53-3 tert-butyl (2S)-2-{[(1-benzyl-2-oxo-1,2-dihydropyridin-3-yl)carbonyl]amino}-5-{[(2,2,5,7,8-pentamethyl-3,4-dihydro-2H-chromen-6-yl)sulfonyl]carbamimidamido}pentanoate 
• 1037088-71-3 methyl (2S)-{[(1-benzyl-2-oxo-1,2-dihydropyridin-3-yl)carbonyl]amino}-(3-nitrophenyl)acetate 
• 1037082-85-1 methyl (2R)-2-{[(1-benzyl-2-oxo-1,2-dihydropyridin-3-yl)carbonyl]amino}-5-{[(2,2,5,7,8-pentamethyl-3,4-dihydro-2H-chromen-6-yl)sulfonyl]carbamimidamido}pentanoate 
• 863395-22-6 1,1'-dibenzyl-3,3'-(N-benzyliminodicarbonyl)di-2-pyridone 
• 863395-21-5 1,1'-dibenzyl-3,3'-(N-butyliminodicarbonyl)di-2-pyridone 
• 863395-20-4 1,1'-dibenzyl-3,3'-(N-isopropyliminodicarbonyl)di-2-pyridone 
• 68359-23-9 1,2-dihydro-2-oxo-1-benzyl-3-pyridinecarboxylic acid chloride 

Relevant articles and documents

Rhodium-Catalyzed C4-Selective C-H Alkenylation of 2-Pyridones by Traceless Directing Group Strategy

A rhodium-catalyzed C4-selective C-H alkenylation of 3-carboxy-2-pyridones with styrenes has been developed. The carboxylic group at the C3 position works as the traceless directing group, and the corresponding C4-alkenylated 2-pyridones are obtained exclusively with concomitant decarboxylation. Unlike the reported procedures, the exclusive C4 selectivity is uniformly observed even in the presence of potentially more reactive C-H bonds at the C5 and C6 positions. By using this strategy, the multiply substituted 2-pyridone can be prepared via sequential C-H functionalization reactions.

IMMUNOMODULATORY COMPOUNDS

Disclosed are immunomodulatory compounds, pharmaceutical compositions containing them, and methods of making and using the compounds to treat diseases and disorders characterized by aberrant protein activity that can be targeted by cereblon.

Creation of concave-shaped conformation in crystal structures using an iminodicarbonyl linker. An application to solid-state intramolecular [4 + 4] photocycloaddition reactions of 2-pyridone derivatives

Single-crystal X-ray structures of 6 carboxamides possessing two units of 2-pyridone moieties connected with an iminodicarbonyl linker were examined to show the usefulness of this linker for the creation of concave-shaped conformation in crystal structure