89960-36-1

Usage

Uses

Used in Pharmaceutical Industry:
1-BENZYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLIC ACID is used as a therapeutic agent for its anti-inflammatory and antioxidant properties, which can contribute to the treatment of various medical conditions.
Used in Cosmetics and Skincare Industry:
1-BENZYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLIC ACID is used as an ingredient in cosmetics and skincare products for its beneficial effects on the skin, potentially improving skin health and appearance.
Used in Neurodegenerative Disease Treatment:
1-BENZYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLIC ACID is studied for its potential use in the treatment of neurodegenerative diseases, due to its therapeutic properties that may help alleviate symptoms or slow disease progression.
Used in Diabetes Management:
1-BENZYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLIC ACID is being researched for its potential role in managing diabetes, possibly through its effects on glucose metabolism and insulin sensitivity.

InChI:InChI=1/C13H11NO3/c15-12-11(13(16)17)7-4-8-14(12)9-10-5-2-1-3-6-10/h1-8H,9H2,(H,16,17)

Upstream product

• 609-71-2 2-hydroxy-3-carboxypyridine 
• 100-39-0 benzyl bromide 
• 400082-66-8 methyl 1-benzyl-2-oxo-1,2-dihydropyridine-3-carboxylate 
• 2942-59-8 2-chloronicotinic acid 

Downstream Products

• 68359-23-9 1,2-dihydro-2-oxo-1-benzyl-3-pyridinecarboxylic acid chloride 
• 863395-20-4 1,1'-dibenzyl-3,3'-(N-isopropyliminodicarbonyl)di-2-pyridone 
• 863395-21-5 1,1'-dibenzyl-3,3'-(N-butyliminodicarbonyl)di-2-pyridone 
• 863395-22-6 1,1'-dibenzyl-3,3'-(N-benzyliminodicarbonyl)di-2-pyridone 
• 1753-62-4 N-benzyl-2-pyridone 
• 1037082-53-3 tert-butyl (2S)-2-{[(1-benzyl-2-oxo-1,2-dihydropyridin-3-yl)carbonyl]amino}-5-{[(2,2,5,7,8-pentamethyl-3,4-dihydro-2H-chromen-6-yl)sulfonyl]carbamimidamido}pentanoate 
• 1037088-71-3 methyl (2S)-{[(1-benzyl-2-oxo-1,2-dihydropyridin-3-yl)carbonyl]amino}-(3-nitrophenyl)acetate 
• 1037082-85-1 methyl (2R)-2-{[(1-benzyl-2-oxo-1,2-dihydropyridin-3-yl)carbonyl]amino}-5-{[(2,2,5,7,8-pentamethyl-3,4-dihydro-2H-chromen-6-yl)sulfonyl]carbamimidamido}pentanoate 

Relevant academic research and scientific papers

Rhodium-Catalyzed C4-Selective C-H Alkenylation of 2-Pyridones by Traceless Directing Group Strategy

A rhodium-catalyzed C4-selective C-H alkenylation of 3-carboxy-2-pyridones with styrenes has been developed. The carboxylic group at the C3 position works as the traceless directing group, and the corresponding C4-alkenylated 2-pyridones are obtained exclusively with concomitant decarboxylation. Unlike the reported procedures, the exclusive C4 selectivity is uniformly observed even in the presence of potentially more reactive C-H bonds at the C5 and C6 positions. By using this strategy, the multiply substituted 2-pyridone can be prepared via sequential C-H functionalization reactions.

Domino Decarboxylative Arylation and C-O Selective Bond Formation toward Chromeno[2,3- b]pyridine-2-one Skeletons

Practical Pd-catalyzed 2-pyridones were designed to achieve chromeno[2,3-b]pyridine-2-ones. The reaction proceeds through domino nucleophilic addition and decarboxylative arylation, respectively. This methodology offers a moderately efficient approach to construct the bioactive, fused-heterocyclic skeletons via selective C-O bond formation and decarboxylative arylation in a single step with high selectivity and good yields.

IMMUNOMODULATORY COMPOUNDS

Disclosed are immunomodulatory compounds, pharmaceutical compositions containing them, and methods of making and using the compounds to treat diseases and disorders characterized by aberrant protein activity that can be targeted by cereblon.

MODULATORS OF C3A RECEPTOR AND METHODS OF USE THEREOF

Provided are compounds that are modulators of C3a receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, the compounds are pyridones. In certain embodiments, provided are methods for treatment or amelioration of diseases associated with modulation of C3a receptor activity.

Creation of concave-shaped conformation in crystal structures using an iminodicarbonyl linker. An application to solid-state intramolecular [4 + 4] photocycloaddition reactions of 2-pyridone derivatives

Single-crystal X-ray structures of 6 carboxamides possessing two units of 2-pyridone moieties connected with an iminodicarbonyl linker were examined to show the usefulness of this linker for the creation of concave-shaped conformation in crystal structure