900-91-4Relevant academic research and scientific papers
Molecular and supramolecular helicity induction in trityl group-containing compounds: The case of chiral 3,3,3-triphenylpropionic acid derivatives
Skowronek, Pawe?,Czapik, Agnieszka,Rajska, Zuzanna,Kwit, Marcin
, p. 4497 - 4505 (2019/07/08)
The process of dynamic chirality transmission from permanent chirality element to stereodynamic triphenylmethyl group placed in the distance of 4 bonds, has been studied for series of optically active 3,3,3-triphenylpropionic acid derivatives. Structural
Amphiphilic agents for membrane protein solubilization
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, (2008/06/13)
Disclosed are amphiphilic compounds comprising Formula I: wherein R1, R2, and R3 are C2-C12 straight or branched alkyl; unsubstituted phenyl, biphenyl, C3-C8 cycloalkyl, or Csub
Carbon-Skeletal Anionic Rearrangements and the ?-Orbital Overlap Constraint: The Question of Nucleophilic Attack versus Electron Transfer
Eisch, John J.,Kovacs, Csaba A.,Chobe, Prabohd
, p. 1275 - 1284 (2007/10/02)
In order to evaluate the geometrical requirements and the actual electronic nature of apparent anionic rearrangements of metalated aromatic hydrocarbons, amines, and ethers, cyclic structural types of such anions were generated as lithium salts by proton abstraction from C-H bonds by RLi or by C-Cl bond cleavage by Li.The cyclic systems examined were anions of 9,9-dimethyl-, 9-methyl-9-benzyl-, and 9-benzyl-9-phenylfluorenes; 9-methyl-9-phenyl-, 9,9-diphenyl-, and 9,9-(2,2'-biphenylene)-9,10-dihydrophenanthrenes; 5-methyl- and 5-phenyl-5,6-dihydrophenathridines;and 9H-dibenzopyran.The anions generated from 9-methyl-9-benzylfluorene, 9-benzyl-9-phenylfluorene, 5-methyl-5,6-dihydrophenanthridine, and 9H-dibenzopyran, as well as 9-methyl-9-(lithiomethyl)fluorene, did not undergo skeletal rearrangement when heated between 40 and 120 deg C for protracted periods.However, the anions derived from the 9-methyl-9-phenyl-, 9,9-diphenyl-, and 9,9-(2,2'-biphenylene)-9,10-dihydrophenanthrenes did undergo rearrangement with a shift of the 9-aryl group.With the anion of 5-phenyl-5,6-dihydrophenanthridine, some shift of the 5-phenyl was observed, but the principal rearrangement was ring contraction with the formation of N-phenyl-9-fluorenylamine.By noting which anions underwent skeletal rearrangement and which competing migrating groups in a given anion underwent a shift preferentially, we have formulated an appropriate geometrical view of the transition states involved.Furthermore, by generating the 2,2,2-triphenylethyl anion (as its lithium salt) from (a) 2-chloro-1,1,1-triphenylethane and Li, (b) 2-bromo-1,1,1-triphenylethane and n-BuLi, and (c) bis(2,2,2-triphenylethyl)mercury and n-BuLi, we attempted to learn whether such shifts were truly nucleophilic or whether SET processes were involved.Evidence for SET processes was obtained for the generation of (2,2,2-triphenylethyl)lithium by method a, but no ESR or CIDNP evidence for radical intermediates was observable when (2,2,2-triphenylethyl)lithium was produced by method c.
1-(3,3,3-Triarylalkyl)-4-phenyl-piperidinealkanols
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, (2008/06/13)
The present invention encompasses compounds of the formula STR1 and pharmaceutically acceptable acid addition salts thereof wherein the Alk is straight or branched chain alkylene containing 2-4 carbon atoms; M is alkylene having 1-4 carbon atoms; Ar and Ar' are phenyl, alkyl substituted phenyl wherein the alkyl contains from 1-4 carbon atoms or halo substituted phenyl; Ar" is phenyl, alkyl substituted phenyl wherein the alkyl contains 1-4 carbon atoms, halo substituted phenyl or pyridyl; X is hydrogen, halogen, trifluoromethyl or alkyl having from 1-4 carbon atoms; R is hydrogen alkyl having from 1-7 carbon atoms or an alkanoyl having from 2-5 carbon atoms. These compounds are potent antidiarrheal agents characterized by little, if any, central nervous system activity.
