90035-08-8 Usage
Description
Flocoumafen is a second-generation anti-coagulant that is primarily used as a rodenticide. It is an off-white solid with limited solubility in water and some organic solvents, and is stable to hydrolysis. Due to its high toxicity, it is restricted to indoor use and sewers in some regions, mainly to minimize the risk to non-target species.
Uses
Used in Pest Control:
Flocoumafen is used as a rodenticide to control rodents around buildings, providing an effective solution for managing these pests in various settings.
Used in Agriculture:
Flocoumafen is utilized in field and plantation crops, including cocoa, cotton, oil palm, rice, and sugar cane, to protect these crops from rodent damage.
Used in Indoor and Sewer Applications:
Due to its high toxicity and the risk to non-target species, flocoumafen is restricted to indoor use and sewers in the United Kingdom, ensuring that its application is limited to areas where the potential impact on wildlife is minimized.
Used in Resistance Management:
Flocoumafen has been shown to effectively control rodents that have developed resistance to first-generation anti-coagulants, making it a valuable tool in managing resistance in rodent populations.
Metabolic pathway
Flocoumafen exists as cis and trans isomers (Scheme 1). The tetralin ring
adopts its most stable conformation in each case and the two forms have
very similar shapes. Both are active rodenticides. The fate of flocoumafen
in soils and plants has not been studied in detail because the compound is
usually used as a pelleted bait or in a wax block. This limits its dissipation
in the environment. Studies in animals and birds have been conducted
as part of the assessment of safety and to investigate mode of action.
Metabolism is slow in the rat and rapid in Japanese quail but this difference
should be interpreted with care because of the 100-fold difference
in dose used (see also Overview).
Degradation
Flocoumafen is a stable compound; no detectable degradation occurs at
50 °C at pH 7-9 over 4 weeks.
Check Digit Verification of cas no
The CAS Registry Mumber 90035-08-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,0,3 and 5 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 90035-08:
(7*9)+(6*0)+(5*0)+(4*3)+(3*5)+(2*0)+(1*8)=98
98 % 10 = 8
So 90035-08-8 is a valid CAS Registry Number.
InChI:InChI=1/C33H25F3O4/c34-33(35,36)24-13-9-20(10-14-24)19-39-25-15-11-21(12-16-25)23-17-22-5-1-2-6-26(22)28(18-23)30-31(37)27-7-3-4-8-29(27)40-32(30)38/h1-16,23,28,37H,17-19H2
90035-08-8Relevant articles and documents
Simple synthesis and biological evaluation of flocoumafen and its structural isomers
Jung, Jae-Chul,Jang, Soyong,Oh, Seikwan,Park, Oee-Sook
, p. 833 - 838 (2011/10/04)
Simple synthesis and biological properties of flocoumafen 1 and its structural isomers are described. The key synthetic strategies involve Knoevenagel condensation, Grignard reaction, intramolecular ring cyclization and coupling reaction. Flocoumafen 1 was easily separated into cis and trans forms using flash column chromatography. They were then evaluated for suppression of LPS-induced NO generation and anti-excitotoxicity in vitro. It was found that the trans-flocoumafen was potent suppressor of NO generation with the concentration of 10 μM in vitro, while no significant effect for neurotoxicity in cultured cortical neurons. Indian Academy of Sciences.
Separation of isomers
-
, (2008/06/13)
Process for selective removal of the cis-isomer and consequent enrichment of a solution with respect to the trans-isomer of a 1-(4-hydroxycoumarin-3-yl)-3-substituted phenyl)tetrahydronaphthalene rodenticide by crystallization from hot solvent.