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Methyl cellulose
Cas No: 9004-67-5
No Data No Data No Data AmoyChem Co.,Ltd Contact Supplier
Methyl cellulose Manufacturer/High quality/Best price/In stock
Cas No: 9004-67-5
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High quality Methyl Cellulose supplier in China
Cas No: 9004-67-5
No Data 1 Metric Ton 30 Metric Ton/Month Simagchem Corporation Contact Supplier
Methyl Cellulose (MC) CAS NO.9004-67-5
Cas No: 9004-67-5
USD $ 1.0-3.0 / Metric Ton 1 Metric Ton 10 Metric Ton/Day Hebei yanxi chemical co.,LTD. Contact Supplier
Methyl Cellulose (MC)
Cas No: 9004-67-5
USD $ 2.0-3.0 / Kilogram 1 Kilogram 100 Metric Ton/Week EAST CHEMSOURCES LIMITED Contact Supplier
9004-67-5, Safety delivery High purity methyl cellulose
Cas No: 9004-67-5
USD $ 10.0-20.0 / Gram 100 Gram 10 Metric Ton/Month WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
Top grade Methyl cellulose cas no.9004-67-5
Cas No: 9004-67-5
No Data 1 Kilogram 1000 Metric Ton/Week Hebei Guanlang Biotechnology Co., Ltd. Contact Supplier
Perfect Emulsifier, Thickener Methyl Cellulose (MC) CAS #9004-67-5
Cas No: 9004-67-5
USD $ 38.0-50.0 / Kilogram 25 Kilogram 100 Metric Ton/Month Xi'an Julong Bio-Tech Co., Ltd. Contact Supplier
Cas No: 9004-67-5
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
Factory Supply Methyl cellulose CAS 9004-67-5
Cas No: 9004-67-5
No Data 200 Gram 4000 Metric Ton/Day Ality Chemical Corporation Contact Supplier

9004-67-5 Usage

Fire Hazard

Flash point data for Methyl cellulose are not available; however, Methyl cellulose is probably combustible.


Thickener for aqueous and non-aqueous systems, clear films with grease resistance, binders, lubricants, steric stabilizer and water retention aid.

Air & Water Reactions

Methyl cellulose is hygroscopic. Swells in water to a viscous, colloidal solid. Slightly water soluble.

Limited application

FAO /WHO (1984) Citrus canned; 10Mg/kg (as an anti-haze agent); cold drinks 10g/kg.
According to Japanese regulations (1990), the maximum amount is 2% (used alone or the combination amount together with calcium carboxymethyl cellulose, sodium carboxymethyl cellulose, sodium carboxymethyl starch, sodium starch phosphate).
It can also be used as the emulsion stabilizer of ice cream with the amount being 0.05%; salad sauces being 0.75%; for bread corruption prevention and surface homogenization, use 0.2% to 0.3%.
For application in citrus canned to prevent precipitation of hesperidins and the anti-clounding agent in the juice, use 10~30mg/kg.


It can be used as thickeners; stabilizer; emulsifier; excipients; dispersant; binders; substitutes of film-forming agent hydrosol. It can also be used in mayonnaise, shortenings and some other foods. Because of that the materials can’t digested in the body, it can maintain several times amount of water, resulting in satiety; it can be used in crackers, waffles and other food for taking effect. For application, first 1/5 of the required amount of water for moistening the powder, together with cold water (necessary, to add ice) for mixing well. EEC: approved for using at frozen foam products, potato chips, soft drinks, special dietary foods, baked goods filling, the top material for foaming, sauces, and sauces.
It can also be used in mayonnaise, shortenings and some other foods.
Because of that the materials can’t digested in the body, it can maintain several times amount of water, resulting in satiety; it can be used in crackers, waffles and other food for taking effect.
For application, first 1/5 of the required amount of water for moistening the powder, together with cold water (necessary, to add ice) for mixing well. EEC: approved for using at frozen foam products, potato chips, soft drinks, special dietary foods, baked goods filling, the top material for foaming, sauces, and sauces.
The product is widely used in the architecture industry such as the mixture agent for cement, plaster, and clay seams. It can also be used as adhesive film-forming agent in cosmetics, medicine, and food industry; also can be used as sizing agents for spinning, and printing and dyeing, synthetic resin dispersing agent, paint film formers and thickeners. Methyl cellulose is a very stable material which is resistant to acid, alkalis, microorganisms, and heating. It can be excrete out from the human body without any change. It is used for synthetic resin dispersing agent, film-forming agent of painting, thickener, binder materials, textile sizing agent, and the film-forming agent in the pharmaceutical and food industries.

Production methods

1. Use Pulp to prepare the base fiber; then have etherification reaction to obtain methyl chloride. According to different sources, pulp can be classified into cotton pulp, wood pulp, straw pulp, etc., It is commonly used in industrial of wood pulp and cotton pulp (cotton linters). The cellulose in the pulp itself is difficult to have reaction with methyl chloride; it must first be made into alkali cellulose. Use 1 part of cellulose to be combined with 0.9-1.2 parts of sodium hydroxide and 0.9 to 1.2 parts (all by weight) of water for soak at 30 °C for 1-2h. Then compress to remove excess alkali to obtain the bulk-like alkali cellulose. Break it into pieces to loosen the alkali cellulose and make it more uniform; with the reaction with the oxygen in the air, alkaline cellulose is degraded and its polymerization is also reduced to achieve the purpose of regulating the viscosity. The alkali cellulose which has undergone the above aging process is further suspended in an excess of methyl chloride (typically 10-15 times of the weight of pulp) for taking reaction for about 5h at 60-70 °C to complete the etherification reaction with the corresponding pressure of about 1.7MPa . Post-processing of the products includes washing and drying of the finished product. Is generally washed in hot water of 80-90 °C; add an appropriate amount of hydrochloric acid (or sulfuric acid) for neutralization, and further add it into oxalic acid to make it form complex with iron and heavy metal which is removed together with sodium chloride during the washing step by water. The product was washed and dehydrated, dried to obtain methyl cellulose products.
2. Use alkali to treat wood pulp or cotton, further use methyl chloride to methylate the alkali to obtain the final product. Some industrial products contain small amounts (up to 5%) hydroxyethyl and/or cellulose displaced by hydroxypropyl. For these products, the calculation of content index should follow the percentage of methoxy group plus percentage of ethoxy group and/or percentage of propoxy with "total alkoxy" representing the content.

Chemical Properties

It is a kind of methyl ether of cellulose. It is white or pale yellow or light gray small particles (95% through a 40 mesh sieve), filaments like or powder. It is odorless, tasteless and has hygroscopicity with an apparent density of 0.3~0.7g/mL.
When all the R in the structure is methyl, the substitution degree is equal to 3, and the methoxy content is 45.57%. For methylcellulose used as the food additive, the methoxy content should be around 26%~33% which corresponds to a degree of substitution of 1.7 to 2.2. When the substitution degree is lower than 1.3, it can be dissolved in alkaline. While methylcellulose with substitution degree higher than 2.6 is soluble in an organic solvent. When the degree of substitution is less than 1.3, it can be dissolved in alkali; for those with substitution degree higher than 2.6, it is soluble in organic solution. At the range between 1.3 and 2.6, it is soluble in cold water, pyridine, aniline, trimethyl formamide, benzyl alcohol and acetic acid.
Aqueous solution is stable at neutral and room temperature; but it can generate gelation effect and be precipitated at high temperature. Gelation temperature is dependent on the absolute viscosity and concentration of the solution; solution of large viscosity and high concentration has a relative low gelling temperature. In the presence of inorganic salts, viscosity can be increased. Due to that it belongs to a non-ionic solution, the polyvalent metal is not able to precipitate it; Gelation will only occur when the concentration of the electrolyte and other dissolved substances exceeds a certain limit.
Aqueous solution has surfactant activity and dried to form a thin film; upon heating and cooling, it will orderly go through the reversible transition from the sol to gel.

Reactivity Profile

Methyl cellulose is incompatible with strong oxidizing agents. Methyl cellulose is also incompatible with aminacrine HCl, chlorocresol, mercuric chloride, phenol resorcinol, tannic acid and silver nitrate.

Chemical Properties

white powder or (often) 2% solution in water, properties


ADI does not make special provision (FAO/WHO, 2001).
GRAS (FDA, §182.1480, 2000).

Content Analysis

Measure the methoxy content according to the GT-14 method.


As a substitute for water-soluble gums; to render paper greaseproof, in adhesives, as thickening agent in cosmetics, as protective colloid in emulsions, as binder and stabilizer in foods. As fat replacer in the formulation of dietetic foods. Pharmaceutic aid (suspending agent).

Stability and storage conditions

Methyl cellulose powder is stable and slightly hygroscopic; it should be placed in an airtight container and stored in a cool dry place.
Methyl cellulose solution is sable in diluted acid or base with pH 3 to 11 at room temperature, and is easy to be destroyed by microbes to be corrupted. Therefore, the solution should be added into preservatives or subject to autoclaving. After autoclaving, the change of the solution viscosity is related with pH value. For solution of pH <4, the viscosity will decrease by more than 20% after autoclaving.

General Description

Odorless white or creamy white fibrous powder. Tasteless.


Methylcellulose ether, abbreviated MC, is a kind of long-chain substituted cellulose, in which 27% to 32% of the hydroxyl group exists in the form of methoxy. The substitution degree affects the physical properties of methyl cellulose such as solubility. Methylcellulose has an average molecular weight of 10,000 to 220,000. At room temperature, it exhibits as a white powder or fibrous material, and is non-toxic, non-irritating with non-allergic effect. Its apparent relative density is 0.35 to 0.55 (with the real density being 1.26 to 1.30). It swells in water into a translucent viscous colloidal solution which is neutral to litmus, insoluble in ethanol, ether and chloroform, but soluble in glacial acetic acid. It is tolerant to the effects of acid, alkali, microorganisms, heat, and light and is also not affected by oil and grease, but will burn upon reaching ignition point. Methyl cellulose is a product composed of cellulose glucose with all or part of three hydroxyls getting methylated. General products contain a methoxy fraction of 26% to 33% with degree of substitution being 1.7 to 2.2. Product with substitution degree being 1.3 to 2.6 is soluble in water, pyridine, and acetic acid. This product is widely used for architecture, such as being used as the adhesive of cement, mortar, and for mudding off the seam. It is also used for making film an adhesive in cosmetics, medicine, and food industry. It can be also used as a textile sizing agents, synthetic resin dispersing agent, paint film formers and thickeners. The production method is that: use pulp to produce the alkali cellulose; alkali cellulose is reacted with methyl chloride or dimethyl sulfate in an autoclave and then further refined with warm water to obtain the final product.


Methylcellulose is incompatible for combination with ammonia acridine hydrochloride, chlorine cresol, mercury chloride, phenol, resorcinol, 4-aminobenzoic acid. Inorganic acid, phenol, and tannic acid cause the agglomeration of methyl cellulose; and can also forms complex with tetracaine; it can also bind with parabens so we should increase the amount of parabens upon application.
The above information is edited by the chemicalbook of Dai Xiongfeng.

Brand name

Cologel (Lilly); Methocel A (Dow Chemical).

Herbs and Applications

Methyl cellulose is widely applied in a variety of orally administrated or topical formulations; it is also widely used in cosmetics and food. After oral administration, methyl cellulose can’t be digested or absorbed so that it is a calorie-free material. Excessive intake of methyl cellulose may temporarily increase flatulence and even cause esophageal obstruction upon insufficient water intake. However, methyl cellulose has a laxative effect.
Methyl cellulose is a hydrophilic colloid and is the high-viscosity cellulose derivatives. It is non-toxic and caustic, hygroscopic and can expand into a colloidal suspension in cold water. It is also insoluble in hot water, alcohol, ether, chloroform and saturated salt solution but is soluble in glacial acetic acid and the mixture of equal amount of alcohol and chloroform solution. Its solution may be agglomerated by salts, polybasic acid, phenol and tannin with adding ethanol being able to prevent this agglomeration effect. Methyl cellulose can’t be digested, absorbed in the intestine. It can absorb moisture, mixed with water to form a large volume of hydrophilic gum, and increase the stool volume and soften it, and also stimulate the gut peristalsis to promote the defecation. In patients with diarrhea, because the product can absorb moisture, so it reduces the intestine liquidity to take the antidiarrheal effect.
Oral administration: 1~4g/d together with taking large amounts of water as a bulk laxative for the treatment of constipation. The product has been worked as anorectic agents for controlling appetite and inducing weight loss. But it doesn’t have a reliable effect. Methyl cellulose can also be used as: adhesives which are suitable for choosing low or moderate viscosity grade plastic with both adding powder and solution working well. It is used for improving drug dissolution rate or disintegration rate; the general concentration is 1% to 2%. For gels, thickening gels and creams: it is appropriate to choose high-viscosity grade. Suspending agents and thickening agents, solutions can replace syrup; for thickening, use a concentration of up to 5%. For Tablet coating: we can choose the high-level replacement & low viscosity product as film coating; it can also be used for coating for surrounding the outer nuclear layer for isolation. For disintegrating agents, it is commonly used at a concentration of 2% to 10%. For emulsifier, it is generally recommended to use low-viscosity grade at a concentration of 1% to 5%. For eye drops, we should use high-viscosity grade.

9004-67-5 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
USP (1424506)  Methylcellulose  United States Pharmacopeia (USP) Reference Standard 9004-67-5 1424506-1G 4,662.45CNY Detail
Sigma-Aldrich (64632)  Methylcellulose  tested according to Ph.Eur. 9004-67-5 64632-500G 2,095.47CNY Detail
Sigma-Aldrich (M0555)  Methylcellulose  meets USP testing specifications, viscosity: 1,500 cP 9004-67-5 M0555-500G 2,691.00CNY Detail
Sigma-Aldrich (M0555)  Methylcellulose  meets USP testing specifications, viscosity: 1,500 cP 9004-67-5 M0555-100G 781.56CNY Detail
Sigma-Aldrich (M0430)  Methylcellulose  meets USP testing specifications, viscosity: 400 cP 9004-67-5 M0430-500G 2,676.96CNY Detail
Sigma-Aldrich (M0430)  Methylcellulose  meets USP testing specifications, viscosity: 400 cP 9004-67-5 M0430-100G 776.88CNY Detail
Sigma (M0512)  Methylcellulose  viscosity: 4,000 cP 9004-67-5 M0512-1KG 780.39CNY Detail
Sigma (M0512)  Methylcellulose  viscosity: 4,000 cP 9004-67-5 M0512-500G 459.81CNY Detail
Sigma (M0512)  Methylcellulose  viscosity: 4,000 cP 9004-67-5 M0512-250G 320.58CNY Detail
Sigma (M0512)  Methylcellulose  viscosity: 4,000 cP 9004-67-5 M0512-100G 299.52CNY Detail
Sigma (M0387)  Methylcellulose  viscosity: 1,500 cP 9004-67-5 M0387-1KG 3,258.45CNY Detail
Sigma (M0387)  Methylcellulose  viscosity: 1,500 cP 9004-67-5 M0387-500G 2,102.49CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name methyl cellulose

1.2 Other means of identification

Product number -
Other names -Methylserotonin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:9004-67-5 SDS

9004-67-5Synthetic route

methylene chloride

methylene chloride





Stage #1: cellulose With sodium hydroxide at 30℃; for 1h;
Stage #2: methylene chloride at 75℃; under 4275.43 Torr; for 13h;


methyl iodide

methyl iodide



Stage #1: methylcellulose With sodium hydride In dimethyl sulfoxide; mineral oil at 0 - 50℃;
Stage #2: methyl iodide In dimethyl sulfoxide; mineral oil at 50℃; for 24h;


low molecular weight methylcellulose

low molecular weight methylcellulose

With cellulase In water at 20℃; for 72h;

9004-67-5Downstream Products

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