9004-67-5 Usage
Description
Methyl cellulose is a cellulose derivative in which methoxyl groups replace the hydroxyl groups, making it soluble in cold water but insoluble in hot water. It is known for its thickening, emulsifying, and stabilizing properties, and is widely used in various industries due to its versatility and stability.
Uses
Used in Food Industry:
Methyl cellulose is used as a thickener and emulsifier for various food and cosmetic products, as a gel in advanced cookery, and as a lubricant. It helps in moisture retention in baked goods and reduces water absorption in fruit pie fillings during baking. It is also used as a fat replacer in the formulation of dietetic foods.
Used in Pharmaceutical Industry:
Methyl cellulose serves as a pharmaceutical aid, acting as a suspending agent and excipient. It is also used in the treatment of constipation.
Used in Cosmetic Industry:
In cosmetics, methyl cellulose is used as a thickening agent, protective colloid in emulsions, and as an adhesive film-forming agent.
Used in Paper and Textile Industries:
Methyl cellulose is used as a sizing agent, protecting fibers from water or oil, and as a substitute for water-soluble gums to render paper greaseproof.
Used in Construction Industry:
The product is used as a mixture agent for cement, plaster, and clay seams, providing stability and improved performance in construction materials.
Used in Adhesive and Paint Industries:
Methyl cellulose functions as a synthetic resin dispersing agent, film-forming agent of painting, and thickener, enhancing the quality and performance of adhesives and paints.
Used in Other Applications:
Methyl cellulose is also used as a steric stabilizer, water retention aid, and binder material. It is approved by the EEC for use in frozen foam products, potato chips, soft drinks, special dietary foods, baked goods filling, the top material for foaming, sauces, and sauces. Due to its stability and resistance to acid, alkalis, microorganisms, and heating, it can be excreted from the human body without any change.
Outline
Methylcellulose ether, abbreviated MC, is a kind of long-chain substituted cellulose, in which 27% to 32% of the hydroxyl group exists in the form of methoxy. The substitution degree affects the physical properties of methyl cellulose such as solubility. Methylcellulose has an average molecular weight of 10,000 to 220,000. At room temperature, it exhibits as a white powder or fibrous material, and is non-toxic, non-irritating with non-allergic effect. Its apparent relative density is 0.35 to 0.55 (with the real density being 1.26 to 1.30). It swells in water into a translucent viscous colloidal solution which is neutral to litmus, insoluble in ethanol, ether and chloroform, but soluble in glacial acetic acid. It is tolerant to the effects of acid, alkali, microorganisms, heat, and light and is also not affected by oil and grease, but will burn upon reaching ignition point. Methyl cellulose is a product composed of cellulose glucose with all or part of three hydroxyls getting methylated. General products contain a methoxy fraction of 26% to 33% with degree of substitution being 1.7 to 2.2. Product with substitution degree being 1.3 to 2.6 is soluble in water, pyridine, and acetic acid. This product is widely used for architecture, such as being used as the adhesive of cement, mortar, and for mudding off the seam. It is also used for making film an adhesive in cosmetics, medicine, and food industry. It can be also used as a textile sizing agents, synthetic resin dispersing agent, paint film formers and thickeners. The production method is that: use pulp to produce the alkali cellulose; alkali cellulose is reacted with methyl chloride or dimethyl sulfate in an autoclave and then further refined with warm water to obtain the final product.
Herbs and Applications
Methyl cellulose is widely applied in a variety of orally administrated or topical formulations; it is also widely used in cosmetics and food. After oral administration, methyl cellulose can’t be digested or absorbed so that it is a calorie-free material. Excessive intake of methyl cellulose may temporarily increase flatulence and even cause esophageal obstruction upon insufficient water intake. However, methyl cellulose has a laxative effect.
Methyl cellulose is a hydrophilic colloid and is the high-viscosity cellulose derivatives. It is non-toxic and caustic, hygroscopic and can expand into a colloidal suspension in cold water. It is also insoluble in hot water, alcohol, ether, chloroform and saturated salt solution but is soluble in glacial acetic acid and the mixture of equal amount of alcohol and chloroform solution. Its solution may be agglomerated by salts, polybasic acid, phenol and tannin with adding ethanol being able to prevent this agglomeration effect. Methyl cellulose can’t be digested, absorbed in the intestine. It can absorb moisture, mixed with water to form a large volume of hydrophilic gum, and increase the stool volume and soften it, and also stimulate the gut peristalsis to promote the defecation. In patients with diarrhea, because the product can absorb moisture, so it reduces the intestine liquidity to take the antidiarrheal effect.
Oral administration: 1~4g/d together with taking large amounts of water as a bulk laxative for the treatment of constipation. The product has been worked as anorectic agents for controlling appetite and inducing weight loss. But it doesn’t have a reliable effect. Methyl cellulose can also be used as: adhesives which are suitable for choosing low or moderate viscosity grade plastic with both adding powder and solution working well. It is used for improving drug dissolution rate or disintegration rate; the general concentration is 1% to 2%. For gels, thickening gels and creams: it is appropriate to choose high-viscosity grade. Suspending agents and thickening agents, solutions can replace syrup; for thickening, use a concentration of up to 5%. For Tablet coating: we can choose the high-level replacement & low viscosity product as film coating; it can also be used for coating for surrounding the outer nuclear layer for isolation. For disintegrating agents, it is commonly used at a concentration of 2% to 10%. For emulsifier, it is generally recommended to use low-viscosity grade at a concentration of 1% to 5%. For eye drops, we should use high-viscosity grade.
Stability and storage conditions
Methyl cellulose powder is stable and slightly hygroscopic; it should be placed in an airtight container and stored in a cool dry place.
Methyl cellulose solution is sable in diluted acid or base with pH 3 to 11 at room temperature, and is easy to be destroyed by microbes to be corrupted. Therefore, the solution should be added into preservatives or subject to autoclaving. After autoclaving, the change of the solution viscosity is related with pH value. For solution of pH <4, the viscosity will decrease by more than 20% after autoclaving.
Incompatibility
Methylcellulose is incompatible for combination with ammonia acridine hydrochloride, chlorine cresol, mercury chloride, phenol, resorcinol, 4-aminobenzoic acid. Inorganic acid, phenol, and tannic acid cause the agglomeration of methyl cellulose; and can also forms complex with tetracaine; it can also bind with parabens so we should increase the amount of parabens upon application.
The above information is edited by the lookchem of Dai Xiongfeng.
Content Analysis
Measure the methoxy content according to the GT-14 method.
Toxicity
ADI does not make special provision (FAO/WHO, 2001).
GRAS (FDA, §182.1480, 2000).
Limited application
FAO /WHO (1984) Citrus canned; 10Mg/kg (as an anti-haze agent); cold drinks 10g/kg.
According to Japanese regulations (1990), the maximum amount is 2% (used alone or the combination amount together with calcium carboxymethyl cellulose, sodium carboxymethyl cellulose, sodium carboxymethyl starch, sodium starch phosphate).
It can also be used as the emulsion stabilizer of ice cream with the amount being 0.05%; salad sauces being 0.75%; for bread corruption prevention and surface homogenization, use 0.2% to 0.3%.
For application in citrus canned to prevent precipitation of hesperidins and the anti-clounding agent in the juice, use 10~30mg/kg.
Production methods
1. Use Pulp to prepare the base fiber; then have etherification reaction to obtain methyl chloride. According to different sources, pulp can be classified into cotton pulp, wood pulp, straw pulp, etc., It is commonly used in industrial of wood pulp and cotton pulp (cotton linters). The cellulose in the pulp itself is difficult to have reaction with methyl chloride; it must first be made into alkali cellulose. Use 1 part of cellulose to be combined with 0.9-1.2 parts of sodium hydroxide and 0.9 to 1.2 parts (all by weight) of water for soak at 30 °C for 1-2h. Then compress to remove excess alkali to obtain the bulk-like alkali cellulose. Break it into pieces to loosen the alkali cellulose and make it more uniform; with the reaction with the oxygen in the air, alkaline cellulose is degraded and its polymerization is also reduced to achieve the purpose of regulating the viscosity. The alkali cellulose which has undergone the above aging process is further suspended in an excess of methyl chloride (typically 10-15 times of the weight of pulp) for taking reaction for about 5h at 60-70 °C to complete the etherification reaction with the corresponding pressure of about 1.7MPa . Post-processing of the products includes washing and drying of the finished product. Is generally washed in hot water of 80-90 °C; add an appropriate amount of hydrochloric acid (or sulfuric acid) for neutralization, and further add it into oxalic acid to make it form complex with iron and heavy metal which is removed together with sodium chloride during the washing step by water. The product was washed and dehydrated, dried to obtain methyl cellulose products.
2. Use alkali to treat wood pulp or cotton, further use methyl chloride to methylate the alkali to obtain the final product. Some industrial products contain small amounts (up to 5%) hydroxyethyl and/or cellulose displaced by hydroxypropyl. For these products, the calculation of content index should follow the percentage of methoxy group plus percentage of ethoxy group and/or percentage of propoxy with "total alkoxy" representing the content.
Preparation
Prepared from wood pulp or cotton by treatment with alkali and methylation of alkali cellulose with methyl chloride.
Production Methods
Methylcellulose is prepared from wood pulp (cellulose) by
treatment with alkali followed by methylation of the alkali cellulose
with methyl chloride. The product is then purified and ground to
powder form.
Air & Water Reactions
Methyl cellulose is hygroscopic. Swells in water to a viscous, colloidal solid. Slightly water soluble.
Reactivity Profile
Methyl cellulose is incompatible with strong oxidizing agents. Methyl cellulose is also incompatible with aminacrine HCl, chlorocresol, mercuric chloride, phenol resorcinol, tannic acid and silver nitrate.
Fire Hazard
Flash point data for Methyl cellulose are not available; however, Methyl cellulose is probably combustible.
Pharmaceutical Applications
Methylcellulose is widely used in oral and topical pharmaceutical
formulations;
In tablet formulations, low- or medium-viscosity grades of
methylcellulose are used as binding agents, the methylcellulose
being added either as a dry powder or in solution.Highviscosity
grades of methylcellulose may also be incorporated in
tablet formulations as a disintegrant.Methylcellulose may be added to a tablet formulation to produce sustained-release
preparations.
Tablet cores may also be spray-coated with either aqueous or
organic solutions of highly substituted low-viscosity grades of
methylcellulose to mask an unpleasant taste or to modify the release
of a drug by controlling the physical nature of the granules.
Methylcellulose coats are also used for sealing tablet cores prior to
sugar coating.
Low-viscosity grades of methylcellulose are used to emulsify
olive, peanut, and mineral oils.They are also used as suspending
or thickening agents for orally administered liquids, methylcellulose
commonly being used in place of sugar-based syrups or other
suspension bases.Methylcellulose delays the settling of suspensions
and increases the contact time of drugs, such as antacids, in the
stomach.
High-viscosity grades of methylcellulose are used to thicken
topically applied products such as creams and gels.
In ophthalmic preparations, a 0.5–1.0% w/v solution of a highly
substituted, high-viscosity grade of methylcellulose has been used as
a vehicle for eye drops.However, hypromellose-based formulations
are now preferred for ophthalmic preparations. Methylcellulose
is also used in injectable formulations.
Therapeutically, methylcellulose is used as a bulk laxative; it has
also been used to aid appetite control in the management of obesity,
but there is little evidence supporting its efficacy.
Biochem/physiol Actions
Methyl cellulose is known to have a molecular size that might pass through placenta. It is useful in visualizing small bowel loops through its overlaps.
Safety Profile
A poison by
intraperitoneal route. When heated to
decomposition it emits acrid smoke and
irritating fumes.
Safety
Methylcellulose is widely used in a variety of oral and topical
pharmaceutical formulations. It is also extensively used in cosmetics
and food products, and is generally regarded as a nontoxic,
nonallergenic, and nonirritant material.
Following oral consumption, methylcellulose is not digested or
absorbed and is therefore a noncaloric material. Ingestion of
excessive amounts of methylcellulose may temporarily increase
flatulence and gastrointestinal distension.
In the normal individual, oral consumption of large amounts of
methylcellulose has a laxative action and medium- or high-viscosity
grades are therefore used as bulk laxatives.
Esophageal obstruction may occur if methylcellulose is swallowed
with an insufficient quantity of liquid. Consumption of large
quantities of methylcellulose may additionally interfere with the
normal absorption of some minerals. However, this and the other
adverse effects discussed above relate mainly to the use of
methylcellulose as a bulk laxative and are not significant factors
when methylcellulose is used as an excipient in oral preparations.
Methylcellulose is not commonly used in parenteral products,
although it has been used in intra-articular and intramuscular
injections. Studies in rats have suggested that parenterally
administered methylcellulose may cause glomerulonephritis and
hypertension.Methylcellulose is considered to be toxic by the
intraperitoneal route of administration.
The WHO has not specified an acceptable daily intake of
methylcellulose since the level of use in foods was not considered to
be a hazard to health.
LD50 (mouse, IP): 275 g/kg
storage
Methylcellulose powder is stable, although slightly hygroscopic.
The bulk material should be stored in an airtight container in a cool,
dry place.
Solutions of methylcellulose are stable to alkalis and dilute acids
at pH 3–11, at room temperature. At pH less than 3, acid-catalyzed
hydrolysis of the glucose–glucose linkages occurs and the viscosity
of methylcellulose solutions is reduced.On heating, solution
viscosity is reduced until gel formation occurs at approximately
50°C;
Methylcellulose solutions are liable to microbial spoilage and
antimicrobial preservatives should therefore be used. Solutions may
also be sterilized by autoclaving, although this process can decrease
the viscosity of a solution.The change in viscosity after
autoclaving is related to solution pH. Solutions at pH less than 4 had viscosities reduced by more than 20% subsequent to autoclaving.
Incompatibilities
chlorocresol; mercuric chloride; phenol; resorcinol; tannic acid;
silver nitrate; cetylpyridinium chloride; p-hydroxybenzoic acid; paminobenzoic
acid; methylparaben; propylparaben; and butylparaben.
Salts of mineral acids (particularly polybasic acids), phenols, and
tannins will coagulate solutions of methylcellulose, although this
can be prevented by the addition of ethanol (95%) or glycol
diacetate. Complexation of methylcellulose occurs with highly
surface-active compounds such as tetracaine and dibutoline sulfate.
High concentrations of electrolytes increase the viscosity of
methylcellulose mucilages owing to the ‘salting out’ of methylcellulose.
With very high concentrations of electrolytes, the methylcellulose
may be completely precipitated in the form of a discrete or
continuous gel. Methylcellulose is incompatible with strong
oxidizing agents.
Regulatory Status
GRAS listed. Accepted as a food additive in the USA, Europe and
Japan. Included in the FDA Inactive Ingredients Database
(sublingual tablets; IM injections; intrasynovial injections; nasal
preparations; ophthalmic preparations; oral capsules, oral suspensions,
and oral tablets; topical and vaginal preparations). Included
in nonparenteral medicines licensed in the UK. Included in the
Canadian List of Acceptable Non-medicinal Ingredients.Reported
in the EPA TSCA inventory.
Check Digit Verification of cas no
The CAS Registry Mumber 9004-67-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,0 and 4 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 9004-67:
(6*9)+(5*0)+(4*0)+(3*4)+(2*6)+(1*7)=85
85 % 10 = 5
So 9004-67-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H20O10/c1-21-9-11-13(23-3)15(24-4)18(27-7)20(30-11)31-14-12(10-22-2)29-19(28-8)17(26-6)16(14)25-5/h11-20H,9-10H2,1-8H3/t11?,12?,13?,14-,15?,16?,17?,18?,19?,20+/m1/s1
9004-67-5Relevant articles and documents
Water soluble cellulose etherified derivatives styptic materials
-
Page/Page column 5, (2010/02/15)
The present invention relates to hemostatic materials made of water-soluble cellulose ether derivatives, such as methylcellulose, ethylcellulose, hydroxyethylcellulose, and pharmaceutically acceptable salts of carboxymethylcellulose, especially to hemostatic materials made of water-soluble cellulose ether derivatives capable of being absorbed in live body. The present invention also relates to the use of water-soluble cellulose hemostatic materials for the preparation of internal and external hemostatic articles and pharmaceutical compositions, and hemostatic articles and pharmaceutical compositions thereof.
Triphenylbut-1-ene derivatives and pharmaceutical compositions and uses thereof
-
, (2008/06/13)
The disclosure relates to the compound 1-(p-β-dimethylaminoethoxyphenyl)-cis-1-(p-hydroxyphenyl)-2-phenylbut-1-ene, to pharmaceutical compositions containing it and to the use of the compound to produce an anti-oestrogenic effect in warm-blooded animals.
