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9004-67-5

Basic Information
CAS No.: 9004-67-5
Name: Methyl cellulose
Article Data: 3
Molecular Structure:
Molecular Structure of 9004-67-5 (Methyl cellulose)
Formula: C20H38O11
Molecular Weight: 454.50912
Synonyms: Walsroder MC 20000S;Culminal MC;MAPOLOSE 60SH50;Benecel MO 42;Marpolose M 10000;Methylan SP;
EINECS: 232-674-9
Density: 1.3g/cm³
Melting Point: 290-305 °C
Boiling Point: 507°C at 760 mmHg
Flash Point: 196.3°C
Solubility: soluble in cold water
Appearance: white powder
Safety: 24/25
PSA: 147.68000
LogP: -0.37790
Synthetic route
74-87-3

methylene chloride

cellulose

cellulose

methylcellulose

methylcellulose

Conditions
ConditionsYield
Stage #1: cellulose With sodium hydroxide at 30℃; for 1h;
Stage #2: methylene chloride at 75℃; under 4275.43 Torr; for 13h;
methylcellulose

methylcellulose

74-88-4

methyl iodide

2,3,6-tri-O-methylcellulose

2,3,6-tri-O-methylcellulose

Conditions
ConditionsYield
Stage #1: methylcellulose With sodium hydride In dimethyl sulfoxide; mineral oil at 0 - 50℃;
Stage #2: methyl iodide In dimethyl sulfoxide; mineral oil at 50℃; for 24h;
78.4%
methylcellulose

methylcellulose

low molecular weight methylcellulose

low molecular weight methylcellulose

Conditions
ConditionsYield
With cellulase In water at 20℃; for 72h;
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Chemistry

Molecule structure of Methyl cellulose (CAS NO.9004-67-5):

Water Solubility: soluble in cold water 
EINECS: 232-674-9
Product Categories: Carbohydrates M-OPharmacopoeia (USP); Pharmacopoeia A-ZBiochemicals and Reagents; Carbohydrates; Carbohydrates A to; CarbohydratesCarbohydrates; Core Bioreagents; Polysaccharide; Research Essentials; Carbohydrates M-OBiochemicals and Reagents; CarbohydratesPolymer Science; CelluloseBiochemicals and Reagents; Natural Polymers; Cell Culture; Miscellaneous Reagents and Supplements; Reagents and Supplements; CarbohydratesProtein Electrophoresis; Capillary Electrophoresis; Dynamic Sieving

Uses

  Methyl cellulose (CAS NO.9004-67-5) is used as a variable viscosity personal lubricant; it is the main ingredient in K-Y Jelly. It is often added to hair shampoos, tooth pastes and liquid soaps, to generate their characteristic thick consistency. This is also done for foods. Methyl cellulose is also an important emulsifier, preventing the separation of two mixed liquids. Methyl cellulose is not absorbed by the intestines but passes through the digestive tract undisturbed when eaten. Because it absorbs water and potentially toxic materials and increases viscosity, it can also be used to treat diarrhea. A well-known trade name of Methyl cellulose when used as a drug is Citrucel by GlaxoSmithKline, but generic versions are also widely available. Solutions containing Methyl cellulose or similar cellulose derivatives are used as substitute for tears or saliva if the natural production of these fluids is disturbed. Methyl cellulose , as a gel, has the unique property of setting when hot and melting when cold. This technique is currently being developed at the University of Nottingham. Methyl cellulose is also used in the manufacture of capsules in nutritional supplements, its edible and non-toxic properties provide a safe alternative to the use of gelatin.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 275gm/kg (275000mg/kg)   National Technical Information Service. Vol. AD628-313,
mouse LDLo intravenous 1gm/kg (1000mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 685, 1956.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Safety Statements of Methyl cellulose (CAS NO.9004-67-5): 24/25 
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3
RTECS: FJ5959000
F: 3
A poison by intraperitoneal route. When heated to decomposition it emits acrid smoke and irritating fumes.

Specification

 Methyl cellulose (CAS NO.9004-67-5) is also named as Adulsin ; Avicel SG ; Bagolax ; Benecel M 0 ; Benecel M 02 ; Benecel MC 4000PS ; Celacol M20 ; Celacol M450 ; Celacol MM ; Cellulose methyl ; Cellulose methyl ether ; Cellulose methylate ; FEMA No. 2696 ; HSDB 1198 ; Hi-SM 4000 ; Hydrolose ; MC 20000S ; Mapolose 60SHS0 ; Mapolose M25 ; Mellose ; Methyl cellulose ; Methyl cellulose ether ; Methyl cellulose-A ; Metolose 60SH400 ; Metolose MC 8000 ; Metolose SM 100 ;Tylose MH20 ; Tylose MH2000 ; Tylose MH300 ; Tylose MH300P ; Tylose MH4000 ; Tylose MH50 ; Tylose SAP ; Tylose SL ; Tylose SL 100 ; Tylose SL 400 ; Tylose SL 600 ; Tylose TWA ; UNII-O0GN6F9B2Y ; USP methylcellulose ; Viscol ; Viscontran L52 ; Viscosol ; Walsroder MC 20000S . It is white powder with tasteless. It is hygroscopic. Swells in water to a viscous, colloidal solid. Methyl cellulose is incompatible with strong oxidizing agents. Methyl cellulose is also incompatible with aminacrine HCl, chlorocresol, mercuric chloride, phenol resorcinol, tannic acid and silver nitrate. Flash point data for Methyl cellulose are not available; however, it is probably combustible.