90056-89-6Relevant academic research and scientific papers
PREVENTION AND TREATMENT OF CANCER AND OTHER DISEASES
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Page/Page column 64, (2008/06/13)
Nucleoside chemical compounds, which interact with specific structures of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) are disclosed. The compounds interfere with the activities of telomerase and reverse transcriptase, and are useful as antivirals, antibacterials and anticancer agents. Methods of treating or preventing cancers in patients involving administration of a therapeutically effective amount of a composition having an inhibitor or antagonist of the reverse transcriptases (RTs) expressed in cells of the patients are also disclosed. Method of using nucleoside analogs and other inhibitors of RTs in conjunction with DNA damaging agents such as genotoxic agents or radiation or photodynamic therapy or combinations these for the treatment of various cancers are also disclosed.
Effect of Acyclic Pyrimidines Related to 9-guanine on Herpesviruses
Beauchamp, Lilia M.,Serling, Barbara L.,Kelsey, John E.,Biron, Karen K.,Collins, Peter,et al.
, p. 144 - 149 (2007/10/02)
A series of pyrimidines related to the potent antiherpetic agent 9-guanine (1, BW B759U), all containing the same acyclic chain, have been synthesized.Some of the compounds were derivatives of the naturally occuring bases, cytosine, uracil, and thymine; others included compounds in which the 5-position of the cytosine and uracil moieties were substituted by bromo, iodo, fluoro, methyl, and amino groups.Other variations of the cytosine derivatives were the 5-aza, 2-mercapto, 4-methylamino, 4-dimethylamino, and isocytosine congeners.A 4-aminopyrimidine adduct was also made.Antiviral testing showed that 1-cytosine (18, BW A1117U) was equivalent to the guanine analogue in the potency against human cytomegalovirus and Epstein Barr virus.Other compounds in the series were largely inactive in antiviral screening against the herpesviruses.
Uracil analogues of the acylonucleoside 9--methyl>guanine (BIOLF-62)
Ogilvie, Kelvin K.,Hamilton, Raymond G.,Gillen, Michael F.,Radatus, Bruno K.,Smith, Kendall O.,Galloway, Karen S.
, p. 16 - 21 (2007/10/02)
A series of substituted uracil analogues of the antiviral agent 9-methyl>guanine (BIOL-62) has been synthesized and characterized.The uracil analogues show little activity against herpesviruses.
