900779-69-3

Usage

Uses

Used in Fragrance Industry:
(+/-)-1-Methoxy-4-(trans-2-(trifluoromethyl)cyclopropyl)benzene is used as a fragrance ingredient for its sweet, floral odor. It is incorporated into various products such as perfumes, soaps, and detergents to provide a pleasant scent.
Used in Pharmaceutical Industry:
(+/-)-1-Methoxy-4-(trans-2-(trifluoromethyl)cyclopropyl)benzene may have potential uses in the pharmaceutical industry as a chemical intermediate or as a component in the development of new drugs.
Used in Agrochemical Industry:
This chemical may also have potential uses in the agrochemical industry, possibly as a component in the development of new pesticides or other agricultural chemicals.
Used as a Synthetic Intermediate:
(+/-)-1-Methoxy-4-(trans-2-(trifluoromethyl)cyclopropyl)benzene can be used as a synthetic intermediate in organic chemistry, contributing to the synthesis of more complex molecules and compounds.

Upstream product

• 637-69-4 4-Methoxystyrene 
• 371-67-5 2,2,2-trifluorodiazoethane 
• 373-88-6 2,2,2-trifluroethylamine hydrochloride 
• 2398-37-0 3-methoxyphenyl bromide 
• 135654-49-8 diphenyl(2,2,2-trifluoroethyl)sulfonium trifluoromethanesulfonate 
• 104-92-7 1-bromo-4-methoxy-benzene 

Relevant academic research and scientific papers

Iron-catalyzed cyclopropanation with trifluoroethylamine hydrochloride and olefins in aqueous media: In situ generation of trifluoromethyl diazomethane

Let's avoid the risk! The title transformation has been developed for the synthesis of trifluoromethyl-substituted cyclopropane derivatives (see scheme). It avoids the preparation of trifluoromethyl diazomethane and merges a number of areas: water as a reaction medium, iron catalysis, and access to reactive intermediates under operationally safe conditions. Chemical equation presented

Synthesis of trans-2-(trifluoromethyl)cyclopropanes via suzuki reactions with an N-methyliminodiacetic acid boronate

trans-2-(Trifluoromethyl)cyclopropylboronic acid N-methyliminodiacetic acid (MIDA) ester 5 was synthesized as a pure diastereomer from vinylboronic acid MIDA ester and (trifluoromethyl)diazomethane in a single step. An X-ray study confirmed the trans-stereochemistry around the cyclopropyl ring. Use of 5 in Suzuki reactions, with a variety of aryl or heteroaryl coupling partners, provided trans-2-(trifluoromethyl)cyclopropyl products in moderate to excellent yields (17-90%).

Highly enantioselective synthesis of trifluoromethyl cyclopropanes by using Ru(ii)-Pheox catalysts

An asymmetric synthesis of various trifluoromethyl cyclopropanes from olefins, such as vinyl ferrocene, vinyl ethers, vinyl amines, vinyl carbamates and dienes, was achieved by using Ru(ii)-Pheox catalysts. This catalytic system can function at a low catalyst loading (3 mol%) compared with those reported previously, and the desired cyclopropane products are obtained in high yields with excellent diastereoselectivity (up to >99:1) and enantioselectivity (up to 97% ee).

Highly Diastereo- and Enantioselective Synthesis of Trifluoromethyl-Substituted Cyclopropanes via Myoglobin-Catalyzed Transfer of Trifluoromethylcarbene

We report an efficient strategy for the asymmetric synthesis of trifluoromethyl-substituted cyclopropanes by means of myoglobin-catalyzed olefin cyclopropanation reactions in the presence of 2-diazo-1,1,1-trifluoroethane (CF3CHN2) as

A Trifluoromethylcarbene Source

The trifluoromethylcarbene (:CHCF3) was found to be conveniently generated from (2,2,2-trifluoroethyl)diphenyl-sulfonium triflate (Ph2S+CH2CF3 -OTf), which was successfully applied in Fe-catalyzed cyclopropanation of olefins, giving the corresponding trifluoromethylated cyclopropanes in high yields.

CYCLOPROPYL MIDA BORONATE

This disclosure concerns a protected cyclopropylboronic acid comprising a substituted cyclopropyl group and a boronic ester group having a protecting group. The protecting group is an N-methyliminodiacetic acid (MIDA) group or MIDA-based group.

Enantioselective cobalt-catalyzed preparation of trifluoromethyl- substituted cyclopropanes

Easy access on water: A cobalt-catalyzed asymmetric preparation of trifluoromethylcyclopropanes has been developed that yields high enantioselectivities with a broad range of styrene substrates (see scheme). The reaction presents a new access to enantioen

Asymmetric synthesis of trifluoromethylphenyl cyclopropanes catalyzed by chiral metalloporphyrins

The asymmetric addition of 2,2,2-trifluorodiazoethane to styrene derivatives to give optically active trifluoromethylphenyl cyclopropanes (ee values up to 69%) was carried out by using chiral iron and ruthenium porphyrins as homogeneous and heterogeneous catalysts. Georg Thieme Verlag Stuttgart.