901142-19-6

Upstream product

• 901116-33-4 C₁₆H₁₄ClN₃OS₂ 
• 98-88-4 benzoyl chloride 
• 99585-88-3 2-chloro-N-(4-chlorobenzyl)acetamide 
• 104-86-9 4-chlorobenzylamine 

Relevant academic research and scientific papers

Synthesis, structure-activity relationships and preliminary antitumor evaluation of benzothiazole-2-thiol derivatives as novel apoptosis inducers

A series of novel benzothiazole-2-thiol derivatives were synthesized, and their anti-proliferative activities on HepG2 and MCF-7 cells were investigated. Most compounds had inhibitory effects on cell growth, and some of them were more effective than cisplatin. Compounds 6m and 6t displayed good inhibitory activities against a panel of different types of human cancer cell lines, with IC50 values in the low micromolar range. Further biological evaluation indicated that 6m induced apoptosis in HepG2 cancer cells. Structure-activity relationships were also proposed.