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Upstream product

• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 3055-94-5 2-[2-(2-Dodecyloxy-ethoxy)-ethoxy]-ethanol 
• 75-21-8 oxirane 
• 112-53-8 1-dodecyl alcohol 
• 151-21-3 sodium dodecyl-sulfate 
• 107-21-1 ethylene glycol 
• 115502-59-5 Dodecyloxy-acetic acid methyl ester 
• 1025802-66-7 2-(2-Dodecyloxy-ethoxy)-tetrahydro-pyran 
• 4536-30-5 ethylene glycol mono-n-dodecyl ether 
• 143-15-7 1-dodecylbromide 
• 111-46-6 diethylene glycol 
• 3055-93-4 diethylene glycol monododecyl ether 
• 112-60-7 Tetraethylene glycol 
• 5274-68-0 tetraethylene glycol monododecyl ether 

Downstream Products

• 121971-10-6 1-dodecyloxy-17-trityloxy-3,6,9,12,15-pentaoxa-heptadecane 

Relevant academic research and scientific papers

Nanotitania catalyzes the chemoselective hydration and alkoxylation of epoxides

Glycols and ethoxy– and propoxy–alcohols are fundamental chemicals in industry, with annual productions of millions of tons, still manufactured in many cases with corrosive and unrecoverable catalysts such as KOH, amines and BF3?OEt2. Here we show that commercially available, inexpensive, non–toxic, solid and recyclable nanotitania catalyzes the hydration and alkoxylation of epoxides, with water and primary and secondary alcohols but not with phenols, carboxylic acids and tertiary alcohols. In this way, the chemoselective synthesis of different glycols and 1,4–dioxanones, and the implementation of nanotitania for the production in–flow of glycols and alkoxylated alcohols, has been achieved. Mechanistic studies support the key role of vacancies in the nano–oxide catalyst.

Efficient concrete foam stabilizer and preparation method thereof

The invention discloses an efficient concrete foam stabilizer and a preparation method thereof, according to the efficient foam stabilizer, polyol is subjected to an esterification reaction to form ester bonds, and the ester bonds are connected with amphiphilic side chains, and the number of the amphiphilic side chains is 3-7; one end of the amphiphilic side chain is a hydrophobic chain segment, and the other end of the amphiphilic side chain is a hydrophilic unit; wherein the hydrophobic chain segment is an alkyl chain (R) with 8-14 carbons, and the hydrophilic unit is 2-10 ethylene oxide units. The efficient concrete foam stabilizer is a multi-chain type surfactant, and the multi-chain type surfactant is hydrolyzed under the alkaline condition to release an air-entraining type surfactant. The efficient concrete foam stabilizer has an excellent effect of stabilizing the air content of concrete, meanwhile, hardened concrete has a better pore structure, and the hardening strength of the concrete cannot be greatly influenced.

METHODS OF ETHERIFICATION

Embodiments of the present disclosure are directed towards methods of etherification including reducing templates of a zeolite catalyst to provide a reduced template zeolite catalyst having from 3 to 15 weight percent weight percent of templates maintained following calcination of zeolite catalyst; and contacting the reduced template zeolite catalyst with an olefin and an alcohol to produce a monoalkyl ether.

Nonionic Isatin Surfactants: Synthesis, Quantum Chemical Calculations, ADMET and Their Antimicrobial Activities

The most challenge task in the building up of surface-active molecules is maximizing their surface activity with good biological activity. A nonionic surfactant (N-isatin-EOm-Cn where m is 5, 7 and 9 ethylene glycol units and n is 8, 10 and 12) is achieved by first reacting isatin with chloroacetic acid and then with different types of ethoxylated (C8–C12) fatty alcohols that possess 5, 7 and 9 ethylene oxide units. The prepared surfactants were characterized by FTIR and 1H NMR to confirm the structure. The surface activity, biodegradability, antimicrobial, and antifungal activity of the surfactants were evaluated. In addition, quantum chemical calculations and computations of oral bioavailability were performed. The obtained data show that all the synthesized compounds had good surface activity, biodegradability and biological activity.

Polyoxyethylene ether carboxylic acid dimeric surfactant type drag reducer as well as preparation method and application thereof

The invention discloses a polyoxyethylene ether carboxylic acid dimeric surfactant type drag reducer as well as a preparation method and application thereof. The polyoxyethylene ether carboxylic aciddimeric surfactant type drag reducer has a structure formula m=2, 3, 4, and n=1, 2, 3. The drag reducer disclosed by the invention is a dimeric surfactant type drag reducer which has a head group of carboxylic acid, and the head group has the advantages of being very good in temperature resistance, salt resistance, environment protection and the like, and is capable of overcoming influence of a high-salt environment upon drag reduction performance, so that the drag reducer disclosed by the invention is high in drag reduction efficiency, good in shearing resistance, long-lasting and stable in drag reduction rate and good in salt resistance; and polyoxyethylene ether carboxylic acid dimeric surfactants of different mass concentrations are dissolved into water, a drag reduction solution whichis high in drag reduction efficiency, good in shearing resistance, long-lasting and stable in drag reduction rate and good in salt resistance can be prepared without any other compounded chemical reagent, solution blending steps are simple, the drag reducer is very convenient to use, and meanwhile, the salt resistance is greatly improved.

Drug carrier based on sulfonium lipidosome structure and preparation method and application of drug carrier

The invention relates to the technical field of medicine, in particular to a sulfonium compound shown as a general formula (A), and discloses a preparation method of the compound. The compound is poly-condensed with genes to form a nanometer compound with the particle size of 100-300 nm and Zeta potential of +20-+40. The gene loading capability of the sulfonium compound enables the sulfonium compound to have potential application in gene transfer.

Two Types of Cross-Coupling Reactions between Electron-Rich and Electron-Deficient Alkenes Assisted by Nucleophilic Addition Using an Organic Photoredox Catalyst

Two types of photoreactions between electronically differentiated donor and acceptor alkenes assisted by nucleophilic addition using an organic photoredox catalyst efficiently afforded 1:1 or 2:1 cross-coupling adducts. A variety of alkenes and alcohols were employed in the photoreaction. Control of the reaction pathway (i.e., the formation of the 1:1 or 2:1 adduct) was achieved by varying the concentration of the alcohol used. Detailed mechanistic studies suggested that the organic photoredox catalyst acts as an effective electron mediator to promote the formation of the cross-coupling adducts.

Application of Monodisperse PEGs in Pharmaceutics: Monodisperse Polidocanols

Polydisperse PEGs are ubiquitously used in pharmaceutical industry and biomedical research. However, the monodispersity in PEGs may play a role in the development of safe and effective PEGylated small molecular drugs. Here, to avoid the polydispersity in polidocanol, the active ingredient in a clinically used drug, a macrocyclic sulfate-based strategy for the efficient and scalable synthesis of monodisperse polidocanols, their sulfates, and their methylated derivatives, was developed. TLC and HPLC analysis indicated a complex mixture in regular polidocanol and high purities in monodisperse polidocanols and their derivatives. Assay on HUVEC, L929, and HePG2 cells showed that monodisperse polidocanols have much higher cytotoxicity and safety than that of regular polidocanol. It was found that the monodispersity of PEGs in polidocanols is crucial for achieving the optimal therapeutic results. Therefore, based on this case study, it would be beneficial to optimize PEGylated small molecular drugs with monodisperse PEGs in pharmaceutical research and development.

Preparation method and application of monodisperse nonapolyethylene glycol dodecyl alcohol monoether and sulphate thereof

The invention discloses a preparation method and application of monodisperse nonapolyethylene glycol dodecyl alcohol monoether and sulphate thereof and belongs to the field of pharmaceutical and chemical industry. Starting from dodecyl alcohol, firstly ring-opening reaction is carried out with nonapolyethylene glycol cyclic sulphate once or with multiple oligomeric ethylene glycol cyclic sulphate containing nine ethylene glycol units in total for multiple times in presence of alkali, so that sulphate of nonapolyethylene glycol dodecyl alcohol monoether is obtained; and then hydrolysis is carried out in presence of sulphuric acid, so that the nonapolyethylene glycol dodecyl alcohol monoether is obtained. The preparation method can be applied to preparation of long-chain alkyl monoether of monodisperse polyethylene glycol and sulphate thereof. The preparation method disclosed by the invention has the advantages that single molecular weight polyethylene glycol cyclic sulphate is taken as a raw material, efficient synthesis of more than hexameric alkyl alcohol monoether of ethylene glycol is realized, no protecting group is used during synthesis, steps are simple and convenient, the preparation method is applicable to industrial production, and the obtained product has obvious advantages compared with existing prepared lauromacrogol.

Cationic DOPC–Detergent Conjugates for Safe and Efficient in Vitro and in Vivo Nucleic Acid Delivery

The ability of a nonviral nucleic acid carrier to deliver its cargo to cells with low associated toxicity is a critical issue for clinical applications of gene therapy. We describe biodegradable cationic DOPC–C12E4 conjugates in which transfection efficiency is based on a Trojan horse strategy. In situ production of the detergent compound C12E4 through conjugate hydrolysis within the acidic endosome compartment was expected to promote endosome membrane destabilization and subsequent release of the lipoplexes into cytosol. The transfection efficiency of the conjugates has been assessed in vitro, and associated cytotoxicity was determined. Cellular uptake and intracellular distribution of the lipoplexes have been investigated. The results show that direct conjugation of DOPC with C12E4 produces a versatile carrier that can deliver both DNA and siRNA to cells in vitro with high efficiency and low cytotoxicity. SAR studies suggest that this compound might represent a reasonable compromise between the membrane activity of the released detergent and susceptibility of the conjugate to degradation enzymes in vitro. Although biodegradability of the conjugates had low impact on carrier efficiency in vitro, it proved critical in vivo. Significant improvement of transgene expression was obtained in the mouse lung tuning biodegradability of the carrier. Importantly, this also allowed reduction of the inflammatory response that invariably characterizes cationic-lipid-mediated gene transfer in animals.