902142-51-2

Upstream product

• 68965-62-8 2-bromocyclohex-1-enecarboxylic acid 
• 159389-47-6 2-bromo-1-cyclohexene-1-carbonyl chloride 
• 38127-47-8 2-bromocyclohex-1-ene-1-carbaldehyde 
• 1010098-53-9 2-bromo-1-cyclohexenecarboxylic acid amide 
• 110-13-4 2,5-hexanedione 

Relevant academic research and scientific papers

Palladium-Catalyzed Asymmetric Intramolecular Dearomative Heck Reaction of Pyrrole Derivatives

The Pd-catalyzed asymmetric intramolecular dearomatization of pyrroles via the Heck reaction in the presence of commercially available Pd(OAc)2 and the Feringa ligand is described. Diverse pyrroline derivatives were obtained in excellent yields (up to 99%) with high enantioselectivity (up to 96% ee). The reaction features a wide substrate scope, relatively mild conditions, and useful transformations of the products.

Chemoselective benzylic C-H activations for the preparation of condensed N-heterocycles

Buttoning up: A chemoselective domino reaction including one or two successive C-H activations serves to convert a range of readily available N-arylpyrroles into complex polycondensed N-heterocycles. The reaction is catalyzed by Pd(OAc)2 (5 mol%), and p-Tol3P (10 mol%) is added as the ligand (see scheme; Tol = tolyl).