Organic Letters
ORCID
Letter
(b) Douki, K.; Ono, H.; Taniguchi, T.; Shimokawa, J.; Kitamura, M.;
Fukuyama, T. Enantioselective Total Synthesis of (+)-Hinckdentine A
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B.; Liang, R.-X.; Jia, Y.-X. Enantioselective Dearomative Difunction-
alization of Indoles by Palladium-Catalyzed Heck/Sonogashira
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Heck Cyclization of Aryl Halides to Afford Indolines. Angew. Chem.,
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Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
■
We thank the National Key R&D Program of China
(2016YFA0202900), the National Basic Research Program of
China (2015CB856600), the National Natural Science
Foundation of China (21332009 and 21572252), the Program
of Shanghai Subject Chief Scientist (16XD1404300), and CAS
(XDB20000000 and QYZDY-SSW-SLH012) for generous
financial support.
(4) For selected racemic examples, see: (a) Zhao, L.; Li, Z.-Y.;
Chang, L.; Xu, J.; Yao, H.; Wu, X. Efficient Construction of Fused
Indolines with a 2-Quaternary Center via an Intramolecular Heck
Reaction with a Low Catalyst Loading. Org. Lett. 2012, 14, 2066−
2069. (b) Petrone, D. A.; Yen, A.; Zeidan, N.; Lautens, M.
Dearomative Indole Bisfunctionalization via a Diastereoselective
Palladium-Catalyzed Arylcyanation. Org. Lett. 2015, 17, 4838−4841.
(c) Petrone, D. A.; Kondo, M.; Zeidan, N.; Lautens, M. Pd(0)-
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Y.; Shen, Y.; Jing, H.; Liang, Y.-M. Palladium-Catalyzed Intra-
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F.; Wang, Y.-G.; Xiang, B.; Gao, J.-R.; Jia, Y.-X. Palladium-catalyzed
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J.; Gao, J.-R.; Jia, Y.-X. Spirooxindole synthesis via palladium-
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