90234-41-6Relevant academic research and scientific papers
Evaluation of 4-phenylamino-substituted naphthalene-1,2-diones as tubulin polymerization inhibitors
Yang, Honghao,An, Baijiao,Li, Xingshu,Zeng, Wei
, p. 3057 - 3063 (2018/08/09)
A series of 4-phenylamino-substituted naphthalene-1,2-dione derivatives were prepared and evaluated as effective antiproliferative agents. MTT assays showed that the compounds with a methyl group on the nitrogen linker exhibited potent antiproliferative activities against human cancer cells. The mechanistic study revealed that these compounds could induce mitochondrial depolarization, which resulted in intracellular ROS production, and they also acted as tubulin polymerization inhibitors. Moreover, the typical compound could arrest A549 cells in the G2/M phase, resulting in cellular apoptosis and induced mitotic arrest in A549 cells through disrupting microtubule dynamics.
Tandem Transformation of Nitro Compounds into N-Methylated Amines: Greener Strategy for the Utilization of Methanol as a Methylating Agent
Paul, Bhaskar,Shee, Sujan,Chakrabarti, Kaushik,Kundu, Sabuj
, p. 2370 - 2374 (2017/06/13)
A simple air- and moisture-stable, highly efficient ruthenium NNN pincer complex is reported for the first time to catalyze the tandem transformation of various aromatic and aliphatic nitro compounds into the corresponding N-methylated amines in up to 98 % yield by using methanol as a green methylating agent. Gram-scale reactions of challenging nitro substrates demonstrated the practical application aspects of this catalytic system. Importantly, the N-methylamine moiety could be smoothly introduced to various complex molecular structures without using any expensive palladium/phosphine/amine-based cross-coupling reactions.
Phosphoramidate tantalum complexes for room-temperature C-H functionalization: Hydroaminoalkylation catalysis
Garcia, Pierre,Lau, Ying Yin,Perry, Mitchell R.,Schafer, Laurel L.
, p. 9144 - 9148 (2013/09/12)
A cooled reaction: Phosphoramidate-ClTaMe3 complexes promote the first example of room-temperature hydroaminoalkylation catalysis. This reaction can be realized under solvent-free conditions and with challenging substrates such as styrenes and dialkyl amines. When using a vinylsilane substrate, for the first time the linear regioisomer is obtained preferentially using a Group5 metal. TBS=tert-butyldimethylsilyl, TMS=trimethylsilyl. Copyright
Aromatic iodination: A new investigation on the nature of the mechanism
Fabbrini, Maura,Galli, Carlo,Gentili, Patrizia,Macchitella, Daniele,Petride, Horia
, p. 1516 - 1521 (2007/10/03)
Following a suggestion by the late Lennart Eberson, we have employed the ICl-HFP (HFP being hexafluoropropan-2-ol) system in iodination reactions, and found unambiguous evidence for the occurrence of an ET-mechanism of halogenation. The evidence is based on the use of 'intelligent' substrates, which make it possible to fix the boundaries between the occurrence of an ET-mechanism and of a conventional polar mechanism. In an 'intelligent' substrate, in fact, the nature of the product(s) changes significantly depending on the operating mechanism. The ICl-HFP combination is instrumental to the onset of a one-electron oxidation with electron-rich substrates, followed by halogenation. The most prominent example is that of the electron-rich substrate durene (1,2,4,5-tetramethylbenzene, DUR), when compared to mesitylene (1,3,5-trimethylbenzene, MES): with a 'conventional' iodination system (i.e., I2/ Ag+) and in common solvents, where the polar mechanism holds, durene is less reactive (kMES/kDUR = 46 ± 3), but becomes more reactive (kMES/kDUR = 0.23) in HFP with ICl, where the ET-mechanism takes over. Other substrates also support the onset of ET-pathways in HFP. Finally, a preliminary survey of a biohalogenation reaction induced by laccase indicates the modest occurrence of a polar process of iodination with a few substrates.
