90401-84-6

Usage

Uses

Used in Pharmaceutical Industry:
6-Cyano-1-tetralone is used as a reactant in the preparation of imidazolylmethylenetetrahydronaphthalene derivatives, which are aldosterone synthase inhibitors. These inhibitors play a crucial role in the development of medications for the treatment of hypertension and other cardiovascular diseases by regulating the production of aldosterone, a hormone that affects blood pressure and fluid balance in the body.

Upstream product

• 50878-03-0 N-(5,6,7,8-tetrahydronaphth-2-yl)acetamide 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 3470-50-6 6-Hydroxy-1-tetralone 
• 557-21-1 dicyanozinc 
• 144464-64-2 5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate 
• 151-50-8 potassium cyanide 
• 3470-53-9 6-amino-1-tetralone 
• 544-92-3 copper(I) cyanide 

Downstream Products

• 828926-05-2 5(S)hydroxy-5,6,7,8-tetrahydronaphthalene-2-carbonitrile 
• 321330-31-8 5-amino-5,6,7,8-tetrahydronaphthalene-2-carbonitrile 
• 952675-93-3 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-7,8-dihydronaphthalene-2-carbonitrile 
• 66362-06-9 C₂₀H₂₁NO₅S 
• 66362-09-2 C₁₈H₁₆N₂O₃S 
• 90401-85-7 ethyl 5-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylate 
• 1315479-99-2 (R,S)-5-hydroxy-5,6,7,8-tetrahydronaphthalene-2-carbonitrile 
• 3470-46-0 5-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid 

Relevant academic research and scientific papers

AMINO ACID COMPOUNDS

[Problem] To provide novel compounds that are S1P1 receptor agonists and exhibit an immunosuppressive activities by inducing lymphocyte sequestration in secondary lymphoid tissues. In addition, to provide a pharmaceutical agent which comprises the compounds as an effective component, in particular to provide a therapeutic and/or prophylactic agent for an autoimmune disease and the like. [Solving Means] Amino acid compounds that are represented by the following Formula (1) are provided

Tricyclic oxazolidone derivatives useful as PR modulators

Compounds of the following structure are described: wherein R1-R6, R16, m, V, W, X, Y, and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compounds are use

Oxazolidone derivatives as PR modulators

Compounds of the following structure are described: wherein R1, R2, R5, R6, V, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compounds are useful for treating a variety of hormone-related conditions including contraception, treating or preventing fibroids, endometriosis, dysfunctional bleeding, uterine leiomyomata, polycystic ovary syndrome, or hormone-dependent carcinomas, providing hormone replacement therapy, stimulating food intake or synchronizing estrus.

BICYCLIC COMPOUNDS HAVING BRADYKININ RECEPTORS AFFINITY AND PHARMACEUTICAL COMPOSITIONS THEREOF

Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and

CYCLIC AMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF INFLAMMATION-RELATED DISORDERS MEDIATED BY BRADYKININ

Compounds of formula (I) are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation mediated by Bradykinin. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes wherein q, t, R, Ra, Rb, Rc and R2 are as defined herein.

A short, efficient synthesis of 6-cyano-1-tetralones

A new, short and high-yield synthesis of 6-cyano-1-tetralones is described. Triflate intermediates 8 and 9 are versatile intermediates for the synthesis of other 6-substituted tetralones.