90483-95-7 Usage
Uses
Used in Pharmaceutical Industry:
1-OXO-1,3-DIHYDRO-2-BENZOFURAN-4-CARBONITRILE is used as an intermediate in the synthesis of various pharmaceuticals for its potential role in the development of new drugs and medications. Its unique chemical structure and versatile reactivity contribute to the creation of novel therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 1-OXO-1,3-DIHYDRO-2-BENZOFURAN-4-CARBONITRILE serves as an intermediate in the synthesis of agrochemicals, playing a crucial role in the development of new pesticides and other agricultural chemicals to improve crop protection and yield.
Used in Organic Synthesis:
1-OXO-1,3-DIHYDRO-2-BENZOFURAN-4-CARBONITRILE is utilized as a building block in organic synthesis, particularly for the production of heterocyclic compounds. Its versatile reactivity allows for the creation of a wide range of complex organic molecules with various applications in different industries.
Safety Precautions:
It is important to handle 1-OXO-1,3-DIHYDRO-2-BENZOFURAN-4-CARBONITRILE with care, as it may be harmful if ingested or inhaled and can cause irritation to the skin and eyes. Proper safety measures should be taken during its use and storage to minimize potential health risks.
Check Digit Verification of cas no
The CAS Registry Mumber 90483-95-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,4,8 and 3 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 90483-95:
(7*9)+(6*0)+(5*4)+(4*8)+(3*3)+(2*9)+(1*5)=147
147 % 10 = 7
So 90483-95-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H5NO2/c10-4-6-2-1-3-7-8(6)5-12-9(7)11/h1-3H,5H2
90483-95-7Relevant academic research and scientific papers
Total synthesis and biological evaluation of 22-hydroxyacuminatine
Xiao, Xiangshu,Antony, Smitha,Pommier, Yves,Cushman, Mark
, p. 1408 - 1412 (2007/10/03)
A total synthesis of 22-hydroxyacuminatine, a cytotoxic alkaloid isolated from Camptotheca acuminata, is reported. The key step in the synthesis involves the reaction of 2,3-dihydro-1H-pyrrolo[3,4-b]quinoline with a brominated phthalide to generate a substituted pentacyclic 12H-5,11a-diazadibenzo[b,h] fluoren-11-one intermediate. Despite its structural resemblance to camptothecin and luotonin A, a biological evaluation of 22-hydroxyacuminatine in a topoisomerase I-deficient cell line P388/CPT45 has confirmed that the observed cytotoxicity is not due to topoisomerase I inhibition, even though 22-hydroxyacuminatine has a hydroxyl group that can theoretically hydrogen bond to Asp533. This result is consistent with the hypothesis that π-π stacking is more important than hydrogen-bonding interactions in determining topoisomerase I inhibitor binding in the ternary cleavage complex.
