90483-95-7 Usage
General Description
1-OXO-1,3-DIHYDRO-2-BENZOFURAN-4-CARBONITRILE, also known as BF-4, is a chemical compound belonging to the benzofuran family. It is a colorless solid with a molecular formula C9H7NO2 and a molecular weight of 161.16 g/mol. 1-OXO-1,3-DIHYDRO-2-BENZOFURAN-4-CARBONITRILE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block in organic synthesis, particularly in the production of heterocyclic compounds. BF-4 has potential applications in the development of new drugs and medications due to its unique chemical structure and versatile reactivity. However, it should be handled with care as it may be harmful if ingested or inhaled, and can cause irritation to the skin and eyes.
Check Digit Verification of cas no
The CAS Registry Mumber 90483-95-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,4,8 and 3 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 90483-95:
(7*9)+(6*0)+(5*4)+(4*8)+(3*3)+(2*9)+(1*5)=147
147 % 10 = 7
So 90483-95-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H5NO2/c10-4-6-2-1-3-7-8(6)5-12-9(7)11/h1-3H,5H2
90483-95-7Relevant articles and documents
Total synthesis and biological evaluation of 22-hydroxyacuminatine
Xiao, Xiangshu,Antony, Smitha,Pommier, Yves,Cushman, Mark
, p. 1408 - 1412 (2007/10/03)
A total synthesis of 22-hydroxyacuminatine, a cytotoxic alkaloid isolated from Camptotheca acuminata, is reported. The key step in the synthesis involves the reaction of 2,3-dihydro-1H-pyrrolo[3,4-b]quinoline with a brominated phthalide to generate a substituted pentacyclic 12H-5,11a-diazadibenzo[b,h] fluoren-11-one intermediate. Despite its structural resemblance to camptothecin and luotonin A, a biological evaluation of 22-hydroxyacuminatine in a topoisomerase I-deficient cell line P388/CPT45 has confirmed that the observed cytotoxicity is not due to topoisomerase I inhibition, even though 22-hydroxyacuminatine has a hydroxyl group that can theoretically hydrogen bond to Asp533. This result is consistent with the hypothesis that π-π stacking is more important than hydrogen-bonding interactions in determining topoisomerase I inhibitor binding in the ternary cleavage complex.
