904925-63-9Relevant academic research and scientific papers
Liver-targeting compound with thyroid hormone receptor stimulating agent characteristics and pharmaceutical composition of liver targeting compound
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, (2020/05/30)
The invention belongs to the field of biomedicines, particularly relates to the field of targeting drugs and more specifically relates to a liver-targeting compound with thyroid hormone receptor stimulating agent characteristics and a pharmaceutical compo
A functionally orthogonal ligand-receptor pair created by targeting the allosteric mechanism of the thyroid hormone receptor
Hassan, A. Quamrul,Koh, John T.
, p. 8868 - 8874 (2007/10/03)
Nuclear receptors are ligand-dependent transcription factors that are of interest as potential tools to artificially regulate gene expression. Ligand binding induces a conformational change involving helix-12 which forms part of the dimerization interface
