90600-04-7

Upstream product

• 63-91-2 L-phenylalanine 
• 67-64-1 acetone 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 91373-64-7 (2S)-2-(isopropylamino)-3-phenylpropan-1-ol 
• 129156-86-1 (S)-2-isopropylamino-1-methoxy-3-phenylpropane 

Relevant academic research and scientific papers

Hydrogen bond architecture in crystal structures of N-alkylated hydrophobic amino acids

Herein we present the first systematic investigation of hydrogen bonding patterns and crystal packing arrangements of N-alkylated hydrophobic amino acids, including synthesis and single crystal structure determination of five new compounds.

N-ALKYLATED AMINO ACIDS AND OLIGOPEPTIDES, USES THEREOF AND METHODS FOR PROVIDING THEM.

The invention relates to the synthesis of amphiphilic amino acid derivatives, in particular to a method for the N-alkylation of an unprotected amino acid or the N-terminus of an oligopeptide substrate, comprising reacting said unprotected amino acid or oligopeptide substrate with an alcohol, e.g. a fatty alcohol, in the presence of a homogeneous transition metal catalyst.

Sodium borohydride: A versatile reagent in the reductive N-monoalkylation of α-amino acids and α-amino methyl esters

α-Amino acids and α-amino methyl esters are easily converted to their N-monoalkyl derivatives by a reductive condensation reaction using several carbonyl compounds in the presence of sodium borohydride. This reducing agent has shown a wide versatility with minor but essential procedural variations. The reaction allows the α-monodeuterium labeling of the new N-substituent by use of sodium borodeuteride.

A general method for the preparation of 5-trifluoromethylated oxazoles from α-amino acids

The reactions of N-acyl-N-benzyl-α-amino acids (1) or N-acylprolines (5) with trifluoroacetic anhydride in the presence of pyridine afford 5- trifluoromethyloxazoles (2 or 7) in good yields. The reaction could proceed through the transient formation of me

Pmc-protected amino acid esters as substrates in N-alkylamino acid synthesis

N-alkylamino acids may be synthesised via Mitsunobu reaction of N-(2,2,5,7,8-pentamethylchroman-6-sulphonyl-)-amino acid esters with various alcohols and subsequent deprotection.

ENANTIOSELECTIVE SYNTHESIS OF β-HYDROXY-α-METHYL CARBONYL COMPOUNDS BY ALDOL REACTION

The enantioselective aldol reactions of ketone lithium enolates with aldehydes mediated chiral lithium amides were extensively investigated.The chiral amino ethers 4a-4l and diamines 16a,b were prepared from α-amino acids.The reaction conditions and the s

AN EFFICIENT ONE-STEP REDUCTIVE N-MONOALKYLATION OF α-AMINO ACIDS

Reactions of protection-free α-amino acids with aldehydes or ketones in the presence of sodium cyanoborohydride afforded the N-monoalkylated amino acids in inorganic salt-free form.Application of this method to synthesis of N-alkyl derivatives of biologic