90629-24-6

Upstream product

• 80675-54-3 ((1-(phenylthio)vinyl)oxy)trimethylsilane 
• 98729-75-0 Carbonic acid (R)-1-[(3S,4S)-1-(4-methoxy-benzyl)-2-oxo-4-phenylsulfanylethynyl-azetidin-3-yl]-ethyl ester 4-nitro-benzyl ester 
• 98076-56-3 [(4-Methoxy-benzyl)-amino]-acetic Acid Tert-butyl Ester 
• 98076-58-5 (2S,3S)-3-<(R)-1-hydroxyethyl>-1-(4-methoxybenzyl)-4-oxo-2-azetidinecarboxylic acid 
• 95266-01-6 t-butyl (2S,3S)-3-<(R)-1-hydroxyethyl>-1-(4-methoxybenzyl)-4-oxo-2-azetidinecarboxylate 
• 98076-57-4 (2S,3R)-N-(4-methoxybenzyl)-N-(t-butoxycarbonylmethyl)-2-bromo-3-hydroxybutyramide 
• 98076-61-0 (2S,3S)-1-(4-methoxybenzyl)-3-<(R)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-4-oxo-2-azetidinecarboxylic acid 
• 98076-60-9 t-butyl (2S,3S)-1-(4-methoxybenzyl)-3-<(R)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-4-oxo-2-azetidinecarboxylate 

Downstream Products

• 90694-08-9 (3S,4R)-3-<(R)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-4-<(phenylthiocarbonyl)methyl>-2-azetidinone 
• 102735-71-7 (3S,4R)-4-<<2-(p-nitrobenzyloxycarbonylamino)etylthio>carbonylmethyl>-3-<(R)-1-(p-nitrobenzyloxycarbonyloxy)ethyl>-2-azetidinone 

Relevant academic research and scientific papers

CYCLIZATION REACTION OF N-PROPARGYL EPOXYAMIDE TO ACETYLENIC 2-AZETIDINONE, A PRECURSOR TO THIENAMYCIN AND RELATED CARBAPENEMS

Base treatment of N-propargyl epoxyamide 5 afforded the acetylenic 3-(hydroxyethyl)-2-azetidinone 9a, which was subsequently transformed to phenyl thiolester 2, a versatile intermediate for the carbapenem synthesis.