906673-57-2

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(2-bromophenyl)-1-phenylpropan-2-ol is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the formation of complex molecular structures. Its presence in the synthesis process can lead to the development of new drugs with potential therapeutic applications.
Used in Organic Chemistry:
In the field of organic chemistry, 2-(2-bromophenyl)-1-phenylpropan-2-ol is used as a reagent or a building block for the creation of other organic compounds. Its versatility in reacting with various chemical groups makes it a valuable component in the synthesis of a wide range of organic molecules, including those with potential applications in materials science, agrochemicals, and specialty chemicals.
Used in Research and Development:
2-(2-bromophenyl)-1-phenylpropan-2-ol is also utilized in research and development settings, where its unique properties are explored for potential new applications. Scientists and researchers may investigate its interactions with other compounds, its role in chemical reactions, and its potential as a precursor to new materials or substances with specific properties.

Upstream product

• 6630-33-7 ortho-bromobenzaldehyde 
• 5411-56-3 1-(2-bromophenyl)ethanol 
• 100-52-7 benzaldehyde 
• 5281-18-5 benzaldehyde, hydrazone 
• 2142-69-0 2-bromophenyl methyl ketone 
• 917-64-6 methyl magnesium iodide 
• 36081-66-0 2'-bromo-2-phenylacetophenone 

Downstream Products

• 1569315-69-0 6-benzyl-6-methyl-6H-benzo[c]chromene 

Relevant academic research and scientific papers

Aldehydes as alkyl carbanion equivalents for additions to carbonyl compounds

Nucleophilic addition reactions of organometallic reagents to carbonyl compounds for carbon-carbon bond construction have played a pivotal role in modern chemistry. However, this reaction's reliance on petroleum-derived chemical feedstocks and a stoichiometric quantity of metal have prompted the development of many carbanion equivalents and catalytic metal alternatives. Here, we show that naturally occurring carbonyls can be used as latent alkyl carbanion equivalents for additions to carbonyl compounds, via reductive polarity reversal. Such 'umpolung' reactivity is facilitated by a ruthenium catalyst and diphosphine ligand under mild conditions, delivering synthetically valuable secondary and tertiary alcohols in up to 98% yield. The unique chemoselectivity exhibited by carbonyl-derived carbanion equivalents is demonstrated by their tolerance to protic reaction media and good functional group compatibility. Enantioenriched tertiary alcohols can also be accessed with the aid of chiral ligands, albeit with moderate stereocontrol. Such carbonyl-derived carbanion equivalents are anticipated to find broad utility in chemical bond formation.

Substitution controlled functionalization of ortho -bromobenzylic alcohols via palladium catalysis: Synthesis of chromenes and indenols

An efficient domino Pd-catalyzed transformation of simple ortho-bromobenzyl tertiary alcohols to chromenes is presented. Their formation is believed to proceed via the formation of a five-membered palladacycle, which, in turn, involves in an intermolecular homocoupling with the second ortho- bromobenzyltertiary alcohol to yield the homo-biaryl bond followed by intramolecular C-O bond formation. Interestingly, when there is an allylic substituent on the benzylic carbon atom, a chemoselective switch was observed, which preferred intramolecular Heck coupling and gave indenols. Further, it has been confirmed that the tertiary alcohol functionality is indispensible to give the coupled products, whereas the use of primary/secondary benzylic alcohols furnished the simple carbonyl products via a possible reductive debromination followed by oxidation due to the availability of β-hydrogen(s).