90731-95-6Relevant academic research and scientific papers
Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes
Voigt, Burkhardt,Meijer, Laurent,Lozach, Olivier,Sch?chtele, Christoph,Totzke, Frank,Hilgeroth, Andreas
, p. 823 - 825 (2005)
A series of 1-aza-9-oxafluorenes with functionally varied 3-substituents have been prepared from N-phenoxycarbonyl-4-phenyl-1,4-dihydropyridines and p-benzoquinone and biologically evaluated as inhibitors of various cyclin-dependant kinases. The absence o
SYNTHESIS OF 3-HALO- AND 3-FORMYL-4-ALKYLPYRIDINES
Comins, Daniel L.,Smith, Roy K.,Stroud, Eric D.
, p. 339 - 344 (2007/10/02)
In the presence of a catalytic amount of cuprous iodide, the addition of Grignard reagents to the 1-phenoxycarbonyl salts of 3-halopyridines gives 4-alkyl-3-halo-1-phenoxycarbonyl-1,4-dihydropyridines.The crude dihydropyridines were aromatized with o-chloroanil to give 4-alkyl-3-halopyridines.Several 4-alkylnicotinaldehydes were synthesized in a similar manner from the cyclic acetal (1,3-dioxolane) of 3-pyridinecarboxaldehyde.After aromatization with sulfur, the crude acetals were hydrolyzed with oxalic acid to give the desired pyridinecarboxaldehydes.
