90732-28-8

Basic information

• Product Name: 1H-Indole, 2,3-dihydro-1-(trifluoroacetyl)- (9CI)
• Synonyms: 1H-Indole, 2,3-dihydro-1-(trifluoroacetyl)- (9CI);1-(trifluoroacetyl)indoline;2,2,2-trifluoro-1-(indolin-1-yl)ethanone;Ethanone, 1-(2,3-dihydro-1H-indol-1-yl)-2,2,2-trifluoro-;1H-Indole, 2,3-Dihydro-1-(Trifluoroacetyl)-;1H-Indole, 2,3-Dihydro-1-(Trifluoroacetyl)-(WX690275)
• CAS NO: 90732-28-8
• Molecular Formula: C₁₀H₈F₃NO
• Molecular Weight: 215.1718296
• Product Categories: ACETYLHALIDE
• Mol File: 90732-28-8.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Indole, 2,3-dihydro-1-(trifluoroacetyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 2,3-dihydro-1-(trifluoroacetyl)- (9CI)(90732-28-8)
• EPA Substance Registry System: 1H-Indole, 2,3-dihydro-1-(trifluoroacetyl)- (9CI)(90732-28-8)

Safety Data

• Hazardous Substances Data: 90732-28-8(Hazardous Substances Data)

Usage

Chemical classification

Indole derivative

Physical form

White to light beige crystalline powder

Solubility

Insoluble in water

Common uses

Building block for the production of pharmaceuticals, agrochemicals, and other commercial products; utilized in the development of new materials and technologies

Chemical properties

Trifluoroacetyl derivative with specific reactivity

Interest to researchers

Valuable for specific reactions and processes in organic synthesis and research

Role in industries

Versatile applications and significant contributions to the advancement of various industries.

Upstream product

• 496-15-1 1-indoline 
• 407-25-0 trifluoroacetic anhydride 
• 120-72-9 indole 
• 354-58-5 1,1,1-Trichloro-2,2,2-trifluoroethane 
• 458-85-5 2,2,2-trifluoro-N-(2-phenylethyl)acetamide 
• 5339-85-5 2-aminophenethyl alcohol 
• 76-05-1 trifluoroacetic acid 
• 53848-17-2 2-bromo-6-methylaniline 
• 383-63-1 ethyl trifluoroacetate, 

Downstream Products

• 210691-38-6 1-(2,2,2-trifluoroacetyl)indolin-5-ylsulfonyl chloride 

Relevant articles and documents

One-pot cyclization of 2-aminophenethyl alcohols: A novel and direct approach to the synthesis of N-acyl indolines

(Chemical Equation Presented) A unique one-pot cyclization of 2-aminophenethyl alcohols with carboxylic acids in the presence of PPh 3, CCL4, and NEt3 furnished the formation of N-acyl indolines in good to excellent yields. This new approach provides an efficient, scalable, low-cost, and direct access to the biologically important indolines which are further oxidizable to indoles and oxindoles.

Redox-Neutral Coupling between Two C(sp3)?H Bonds Enabled by 1,4-Palladium Shift for the Synthesis of Fused Heterocycles

The intramolecular coupling of two C(sp3)?H bonds to forge a C(sp3)?C(sp3) bond is enabled by 1,4-Pd shift from a trisubstituted aryl bromide. Contrary to most C(sp3)?C(sp3) cross-dehydrogenative couplings, this reaction operates under redox-neutral conditions, with the C?Br bond acting as an internal oxidant. Furthermore, it allows the coupling between two moderately acidic primary or secondary C?H bonds, which are adjacent to an oxygen or nitrogen atom on one side, and benzylic or adjacent to a carbonyl group on the other side. A variety of valuable fused heterocycles were obtained from easily accessible ortho-bromophenol and aniline precursors. The second C?H bond cleavage was successfully replaced with carbonyl insertion to generate other types of C(sp3)-C(sp3) bonds.

MULTIVALENT RAS BINDING COMPOUNDS

Described herein are compounds that modulate Ras signaling, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with altered Ras signaling. Further described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds and methods of using such compounds in the treatment of cell proliferative disorders, including cancer.