908554-54-1

Upstream product

• 4231-62-3 1-benzoyl-1H-benzotriazole 
• 67-63-0 isopropyl alcohol 
• 93-89-0 benzoic acid ethyl ester 
• 38753-50-3 1-isopropoxy-2-nitrobenzene 
• 98-88-4 benzoyl chloride 
• 95-14-7 1,2,3-Benzotriazole 
• 88-75-5 2-hydroxynitrobenzene 
• 29026-74-2 2-isopropoxy-phenylamine 

Downstream Products

• 953424-11-8 N-(2-isopropoxyphenyl)thiobenzamide 
• 833-50-1 2-phenylbenzo[d]oxazole 

Relevant academic research and scientific papers

Chromium-Catalyzed Activation of Acyl C-O Bonds with Magnesium for Amidation of Esters with Nitroarenes

Here, we report a chromium-catalyzed activation of acyl C-O bonds with magnesium for amidation of esters with nitroarenes. Low-cost chromium(III) chloride shows high reactivity in promoting amidation by using magnesium as reductant and chlorotrimethylsilane as additive. It provides a step-economic strategy to the synthesis of centrally important amide motifs using inexpensive and air-stable nitroarenes as amino sources.

Iodine-mediated cyclisation of thiobenzamides to produce benzothiazoles and benzoxazoles

Synthesis of benzothiazoles by reaction of iodine with thiobenzamides, which do not possess an ortho alkoxy or ester group, is described. The unlikely synthesis of benzoxazoles from reaction of 2-alkoxythiobenzamides with iodine is also reported.