909095-77-8Relevant articles and documents
The development of novel 1,2-dihydro-pyrimido[4,5-c]pyridazine based inhibitors of lymphocyte specific kinase (Lck)
Sabat, Mark,VanRens, John C.,Brugel, Todd A.,Maier, Jennifer,Laufersweiler, Matthew J.,Golebiowski, Adam,De, Biswanath,Easwaran, Vijayasurian,Hsieh, Lily C.,Rosegen, Jeff,Berberich, Steve,Suchanek, Eric,Janusz, Michael J.
, p. 4257 - 4261 (2007/10/03)
This communication details the synthesis, biological activity, and proposed binding mode of a novel class of tri-cyclic derivatives of 1,2-dihydro-pyrimido[4,5-c]pyridazines 1 and 2. The most potent analogs disclosed showed low nanomolar activity for the