93554-97-3

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 151-50-8 potassium cyanide 
• 83-38-5 2,6-dichlorobenzaldehyde 
• 7677-24-9 trimethylsilyl cyanide 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 

Downstream Products

• 40658-56-8 (+/-)-α-amino-2,6-dichlorobenzeneacetonitrile monohydrochloride 
• 95392-10-2 (2,6-Dichloro-phenyl)-fluoro-acetonitrile 
• 909095-75-6 2-(4-chloro-2-methylsulfanylpyrimidin-5-yl)-1-(2,6-dichlorophenyl)ethanone 
• 95392-16-8 2-(2,6-Dichloro-phenyl)-2-fluoro-ethylamine; hydrochloride 

Relevant academic research and scientific papers

Towards a rational design for resolving agents. Part V; Substituent effects in the resolution of ephedrine using a series of cyclic phosphoric acids

The effects of various aromatic substituents in both ephedrine and a cyclic phosphoric acid on the quality of resolution via diastereomeric salt formation are investigated.The diastereoselective synthesis of a novel series of chloro-substituted ephedrines

HAT INHIBITORS AND METHODS FOR THEIR USE

Compounds having a structure of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b, R3a, R3b, R3c, R4a, R4b, R5, R6, Z and X are as defined herein are provided. Pharmaceutical compositions comprising such compounds and methods for treating various HAT-related conditions or diseases, including cancer, by administration of such compounds are also provided.

PYRAZOLE AMIDE DERIVATIVE

The present invention relates to a novel compound having a function of inhibiting RORγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.

Highly efficient chemo- and regioselective silylation of -OH groups and cyanosilylation of aldehydes promoted by TiCl2(OTf)-SiO2 as a new recyclable catalyst

TiCl2(OTf)-SiO2 as an easy handling recyclable catalyst was applied for trimethylsilylation of diethyl α-hydroxyphosphonates, alcohols and phenols with high selectivity using HMDS as a silylating agent. Cyanotrimethylsilyl ethers were also obtained in excellent yields from treatment of aldehydes with TMSCN in the presence of this catalyst.

Preparation, characterization and catalytic properties of polyaniline-supported metal complexes

Polyaniline-supported Sc, In, Pd, Os and Re catalysts were prepared by using a simple protocol and the thus prepared catalysts were well characterized using FTIR, XPS, UV-Vis/DRS, TGA-DTA. All the catalysts were successfully employed in a wide range of organic transformations such as cyanation and allylation of carbonyl compound, Suzuki coupling of aryl halides and boronic acids, and, most importantly, in asymmetric dihydroxylation of olefins to afford optically active vicinal diols. All the catalysts were separated from the reaction mixture by simple filtration and reused with consistent activity for five cycles without noticeable leaching of metal from the support.

The development of novel 1,2-dihydro-pyrimido[4,5-c]pyridazine based inhibitors of lymphocyte specific kinase (Lck)

This communication details the synthesis, biological activity, and proposed binding mode of a novel class of tri-cyclic derivatives of 1,2-dihydro-pyrimido[4,5-c]pyridazines 1 and 2. The most potent analogs disclosed showed low nanomolar activity for the

A highly efficient and recyclable silica-based scandium(III) interphase catalyst for cyanosilylation of carbonyl compounds

(Chemical Equation Presented) A new silica-based scandium(III) interphase catalyst 2 efficiently catalyzes the cyanosilylation of a variety of aldehydes and ketones. The catalyst shows high thermal stability (up to 300°C) and also is stable in both organi

Imidazolinium-carbodithioate zwitterions as organocatalysts for the cyanosilylation of aldehydes

Imidazolinium-carbodithioates as new organocatalysts have been found to catalyze the cyanosilylation of aldehydes in 100% conversion and good yields. The catalysts could be easily recovered during flash column chromatography.

A NOVEL SYNTHESIS OF α-FLUOROOACETONITRILES. APPLICATION TO A CONVENIENT PREPARATION OF 2-FLUORO-2-PHENETYLAMINES

α-Fluorophenylacetonitriles (3) are readily prepared by the treatment of the corresponding benzaldehyde cyanohydrin trimethylsilylethers (2) with diethylaminosulfur trifluoride (DAST).This method for the introduction of fluorine alpha to the cyano group is also applicable to the cyanohydrin trimethylsilylethers of aromatic ketones.Diborane reduction of the α-fluorophenylacetonitriles (3) yields 2-fluoro-2-phenethylamines (4).