90991-20-1

Basic information

• Product Name: 4-(3-nitro-phenyl)-4-oxo-butyric acid methyl ester
• Synonyms: 4-(3-nitro-phenyl)-4-oxo-butyric acid methyl ester
• CAS NO: 90991-20-1
• Molecular Weight: 237.212
• Mol File: 90991-20-1.mol

Chemical Properties

• CAS DataBase Reference: 4-(3-nitro-phenyl)-4-oxo-butyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-nitro-phenyl)-4-oxo-butyric acid methyl ester(90991-20-1)
• EPA Substance Registry System: 4-(3-nitro-phenyl)-4-oxo-butyric acid methyl ester(90991-20-1)

Safety Data

• Hazardous Substances Data: 90991-20-1(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 6328-00-3 4-(3-nitro-phenyl)-4-oxo-butyric acid 

Downstream Products

• 1241052-08-3 1-(3-nitrophenyl)-1,4-butanediol 
• 58897-79-3 C₁₁H₉NO₅ 
• 175437-06-6 2-{[3-(5-Oxo-tetrahydro-furan-2-yl)-phenylamino]-methylene}-malonic acid diethyl ester 
• 175437-08-8 2-{[3-(6-Oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-methylene}-malonic acid diethyl ester 
• 112607-13-3 5-(3-nitro-phenyl)-tetrahydrofuran-2-one 
• 175436-93-8 5-(3-Amino-phenyl)-dihydro-furan-2-one 
• 21282-91-7 6-(3'-amino phenyl)-2,3,4,5-tetrahydro pyridazin-3-one 
• 198544-28-4 4-(3-Amino-phenyl)-4,4-difluoro-butyric acid methyl ester 
• 198544-29-5 4-{3-[Bis-(2-hydroxy-ethyl)-amino]-phenyl}-4,4-difluoro-butyric acid methyl ester 
• 198544-30-8 4-{3-[Bis-(2-chloro-ethyl)-amino]-phenyl}-4,4-difluoro-butyric acid methyl ester 
• 175436-91-6 4-Hydroxy-4-(3-nitro-phenyl)-butyric acid methyl ester 
• 52239-76-6 3-(m-Nitrophenyl)-6-oxo-1,4,5,6-tetrahydropyridazine 
• 2051-95-8 succinylbenzene 
• 198544-26-2 4,4-Difluoro-4-(3-nitro-phenyl)-butyric acid methyl ester 

Relevant articles and documents

Synthesis of 4-[3′-bis(2″-chloroethyl) aminophenyl] -4,4-difluorobutanoic acid [4,4-difluoro-meta-chlorambucil]

The synthetic sequence to make 4-[4′-bis(2″-chloroethyl)aminophenyl]-4,4-difluorobutanoic acid {4,4-difluorochlorambucil} was not taken beyond the intermediate stage involving methyl 4,4-difluoro-4-(4′-aminophenyl) butanoate, since this amine was hydrolytically unstable. Reaction of methyl 4-(3′-nitrophenyl)-4-oxobutanoate with sulfur tetrafluoride, followed by hydrogenation, afforded the stable isomer, methyl 4,4-difluoro-4-(3′-aminophenyl)butanoate. Bis(hydroxyethylation) by treatment with oxirane, conversion of OH to Cl by Ph3P/ CCl4, and then hydrolysis of the ester group, gave 4-[3′-bis(2″-chloroethyl)aminophenyl]-4,4-difluorobutanoic acid {4,4-difluoro-meta-chlorambucil}.

Syntheses and exploration of new biological activities in ethyl 6/7-substituted and 6, 7-disubstituted quinolin-4-one-3-carboxylates

Syntheses of a number of ethyl 1H, 4H-quinolin-4-one-3-carboxylates carrying substituted piperidinedione ring at position 6 (25 and 31-35), tetrahydrofuranone (37) or tetrahydropyridazinone ring (39) at position 7 and hydroxy and hydroxymethyl substituent

Aspects of Tautomerism. 13. Alkaline Hydrolysis of γ-, δ-, and ε-Keto Esters and their Desoxy Analogues. Geometrical Constraints on Keto Participation

The rates of alkaline hydrolysis of methyl β-benzoylpropionate (I), methyl γ-benzoylbutyrate (II) and methyl δ-benzoylvalerate (III) decrease in the order I>II>III.Keto participation is the predominant pathway in the case of γ-keto esters.Evidence has also been obtained for keto participation in the case of δ-keto esters, whereas no such evidence is available in the case of ε-keto esters studied.