91013-48-8Relevant academic research and scientific papers
Diverse Redoxome Reactivity Profiles of Carbon Nucleophiles
Gupta, Vinayak,Yang, Jing,Liebler, Daniel C.,Carroll, Kate S.
, p. 5588 - 5595 (2017)
Targeted covalent inhibitors have emerged as a powerful approach in the drug discovery pipeline. Key to this process is the identification of signaling pathways (or receptors) specific to (or overexpressed in) disease cells. In this context, fragment-base
AMIDE DERIVATIVE COMPOUND
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Paragraph 0131-0134, (2016/10/10)
An embodiment of the present invention relates to an amide derivative compound or benzo [c] [1,2] Cy-azine derivative compound, a prodrug thereof, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, and a solvate thereof. Ano
Iridium-catalyzed direct C-H amidation with weakly coordinating carbonyl directing groups under mild conditions
Kim, Jinwoo,Chang, Sukbok
, p. 2203 - 2207 (2014/03/21)
An iridium-catalyzed direct C-H amidation of weakly coordinating substrates, in particular of those bearing ester and ketone groups, under very mild conditions has been developed. The observed high reaction efficiency was achieved by the combined use of acetic acid and lithium carbonate as additives. Copyright
TRICYCLIC INHIBITORS OF KINASES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES
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Page/Page column 60, (2013/03/26)
The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1, R2, R3, A, B, and n are defined in the description. The present invention relates also to compositions containing sa
PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a] PYRIDINE DERIVATIVES
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Page/Page column 272; 273, (2010/12/29)
This application relates to compounds of the general Formula I and salts thereof, wherein X, R1A, R1B, R2, R3, R4, and R5 are as defined herein. The application also relates to compositions and methods of treatment of hyperproliferative diseases or disorders.
NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE and INFLAMMATORY DISEASES
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Page/Page column 102-103, (2008/12/05)
The present invention relates to compounds of formula (I) that are inhibitors of PDElA, a phosphodiesterase that is involved in the modulation of the degradation of cartilage, joint degeneration and diseases involving such degradation and/or inflammation.
N-alkyl-4-chloro-1H-benzo[c][1,2]thiazine-3-carbaldehyde-2,2-dioxides - New functional benzothiazine derivatives
Volovenko, Yulian,Volovnenko, Tatyana,Popov, Kirill
, p. 1413 - 1419 (2008/09/19)
(Chemical Equation Presented) A synthesis of N-alkyl-4-chloro-1H-benzo[c] [1,2]thiazine-3-carbaldehyde-2,2-dioxides is described. Reactivity of new β-chloroaldehydes is investigated, a number of novel benzo[c][1,2]thiazine derivatives are synthesized and characterized using 1H, 13C-NMR, MS and elemental analysis.
