910642-66-9Relevant academic research and scientific papers
Processes for producing α-halo ketones, α-halohydrins and epoxides
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, (2008/06/13)
Processes for efficiently producing α-halo ketones, α-halohydrins and epoxides on an industrial scale. The prosesses include one for producing an α-halo ketone of general formula (3) by decarboxylating a product of reaction between a carboxilic acid derivative of general formula (1) and a metal enolate prepared from an α-haloacetic acid of general formula (2) or an acceptable salt thereof, one for producing an by reducing the α-halo ketone (3), and one for producing an epoxide (13) by treating the α-halohydrin (11) with a base to effect ring closure. The above prosesses are particularly suitable for producing optically active α-halo ketones, α-halohydrins and epoxides from the corresponding α-amino acid derivatives. STR1
Ureido amino and imino acids, compositions and methods for use
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, (2008/06/13)
Compounds of the formula STR1 wherein X is various amino or imino acids and esters are disclosed. These compounds are useful due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analge
