(S)-[3-Chloro-2-oxo-1-(phenylmethyl)propyl]-carbamic acid,1,1-dimethylethyl ester

Base Information

• Chemical Name: (S)-[3-Chloro-2-oxo-1-(phenylmethyl)propyl]-carbamic acid,1,1-dimethylethyl ester
• CAS No.: 910642-66-9
• Molecular Formula: C₁₅H₂₀ClNO₃
• Molecular Weight: 297.782

Synonyms:(S)-[3-Chloro-2-oxo-1-(phenylmethyl)propyl]-carbamic acid,1,1-dimethylethyl ester

Chemical Property of (S)-[3-Chloro-2-oxo-1-(phenylmethyl)propyl]-carbamic acid,1,1-dimethylethyl ester

Chemical Property:

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Technology Process of (S)-[3-Chloro-2-oxo-1-(phenylmethyl)propyl]-carbamic acid,1,1-dimethylethyl ester

There total 3 articles about (S)-[3-Chloro-2-oxo-1-(phenylmethyl)propyl]-carbamic acid,1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl 2-tert-butoxycarbonylamino-3-phenylpropanoate (51987-73-6,77119-84-7,19901-50-9) + butyl magnesium bromide (693-04-9) + sodium monochloroacetic acid (3926-62-3) → (S)-[3-Chloro-2-oxo-1-(phenylmethyl)propyl]-carbamic acid,1,1-dimethylethyl ester (910642-66-9) + L-?N-(t-butoxycarbonylphenylalanyl)methyl chloride

Guidance literature:

With sulfuric acid; nitrogen; magnesium chloride; diisopropylamine; In tetrahydrofuran; water;

Reference yield: 25.0%

methyl 2-tert-butoxycarbonylamino-3-phenylpropanoate (51987-73-6,77119-84-7,19901-50-9) + chloroacetic acid (79-11-8) → (S)-[3-Chloro-2-oxo-1-(phenylmethyl)propyl]-carbamic acid,1,1-dimethylethyl ester (910642-66-9)

Guidance literature:

With n-butyllithium; chloro-trimethyl-silane; nitrogen; diisopropylamine; In tetrahydrofuran; aqueous NH₄ Cl;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + N-Cbz-L-Phe (1161-13-3) + isobutyl chloroformate (543-27-1) → (S)-[3-Chloro-2-oxo-1-(phenylmethyl)propyl]-carbamic acid,1,1-dimethylethyl ester (910642-66-9)

Guidance literature:

With 4-methyl-morpholine; hydrogenchloride; In tetrahydrofuran; acetic acid;

upstream raw materials:

methyl 2-tert-butoxycarbonylamino-3-phenylpropanoate

butyl magnesium bromide

sodium monochloroacetic acid

chloroacetic acid

Downstream raw materials:

(S)-[3-[Methyl(phenylmethyl)amino]-2-oxo-1-(phenylmethyl)propyl]carbamic acid, 1,1-dimethylethyl ester, p-toluenesulfonate salt

(1S)-[3-chloro-1-(phenylmethyl)-2-hydroxypropyl]carbamic acid,1,1-dimethylethyl ester

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