911300-69-1

Usage

Uses

Used in Pharmaceutical Industry:
6-Chloro-2-Fluoro Benzylamine is used as a key intermediate in the synthesis of various drugs. Its unique structure allows for the development of new pharmaceutical compounds with potential therapeutic applications.
Used in Agricultural Sector:
In the agricultural industry, 6-Chloro-2-Fluoro Benzylamine serves as a building block in the production of pesticides. Its chemical properties contribute to the creation of effective and targeted pest control solutions.
Used in Dye and Pigment Manufacturing:
6-Chloro-2-Fluoro Benzylamine is utilized in the manufacturing of dyes and pigments, where its distinct chemical structure imparts specific color and stability properties to the final products.
Overall, 6-Chloro-2-Fluoro Benzylamine's diverse applications across the pharmaceutical, agricultural, and dye and pigment industries highlight its importance as a versatile and valuable chemical compound.

Upstream product

• 4045-24-3 4-methoxypiperidine 
• 911300-68-0 (4-methoxy-1-piperidinyl)acetonitrile 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 4045-25-4 4-methoxypiperidine hydrochloride 
• 188622-27-7 tert-butyl 4-methoxypiperidine-1-carboxylate 

Downstream Products

• 173337-67-2 5(S)-tert-butoxycarbonylamino-4(S)-hydroxy-7(S)-isopropyl-2(R)-methyl-8-[4-methoxy-3-(3-methoxy-propyloxy)-phenyl]-octanoic acid N-[2-(4-methoxypiperidino)-ethyl] amide 

Relevant academic research and scientific papers

Novel 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl- octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin

The action of renin is the rate-limiting step of the renin-angiotensin system (RAS), a key regulator of blood pressure. Effective renin inhibitors directly block the RAS entirely at source and, thus, may provide a vital weapon for hypertension therapy. Our efforts toward identifying novel small-molecule peptidomimetic renin inhibitors have resulted in the design of transition-state isosteres such as 1 bearing an all-carbon 8-phenyl-octanecarboxamide framework. Optimization of the extended P3 portion of 1 and extensive P2′ modifications provided analogues with improved in vitro potencies in the presence of plasma. X-ray resolution of rh-renin/38a in the course of SAR work surprisingly unveiled the exploitation of a previously unexplored pocket (S3sp) important for strong binding affinities. Several inhibitors demonstrated oral efficacy in sodium-depleted marmosets. The most potent, 38a, induced dose-dependently a pronounced reduction in mean arterial blood pressure, paralleled by complete blockade of active plasma renin, up to 8 h post-dose. Oral bioavailability of 38a was 16% in marmosets.

TRICYCLIC 1,2,4-TRIAZINE OXIDES AND COMPOSITIONS THEREFROM FOR THERAPEUTIC USE IN CANCER TREATMENTS

The invention relates to novel tricyclic 1,2,4-triazine-1-oxides and novel tricyclic 1,2,4-triazine-1,4-dioxides of formula: (I); and to related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.

METHODS OF TREATING ALZHEIMER'S DISEASE USING ARYL ALKANOIC ACID AMIDES

Disclosed are methods for treating Alzheimer’s disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds of formula 1 (1) wherein the variables R1-R8 and X are defined herein.