19006-82-7

Basic information

• Product Name: 6-PHENYL-2-PYRIDONE
• Synonyms: 2-HYDROXY-6-PHENYLPYRIDINE;6-PHENYL-2-PYRIDONE;Phenylpyridone;6-phenyl-2-pyridone95+%;6-PHENYL-2-PYRIDONE 95+% T;6-Phenyl-2(1H)-pyridinone;6-Phenyl-2(1H)-pyridone;6-Phenylpyridine-2-ol
• CAS NO: 19006-82-7
• Molecular Formula: C₁₁H₉NO
• Molecular Weight: 171.2
• EINECS: 242-740-9
• Mol File: 19006-82-7.mol
• Article Data: 12

Chemical Properties

• Melting Point: 197 °C
• Boiling Point: 417.1 °C at 760 mmHg
• Flash Point: 246.1 °C
• Appearance: /
• Density: 1.158 g/cm³
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 6-PHENYL-2-PYRIDONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-PHENYL-2-PYRIDONE(19006-82-7)
• EPA Substance Registry System: 6-PHENYL-2-PYRIDONE(19006-82-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 19006-82-7(Hazardous Substances Data)

Usage

Uses

6-Phenylpyridin-2(1H)-one is used as a reactant in the preparation of phenylaminopyrimidinones and its derivatives as orally active nonpeptidic inhibitors of human neutrophil elastase.

Upstream product

• 56162-63-1 6-phenyl-2-hydroxypyridine-3-carboxylic acid 
• 10413-00-0 5-oxo-5-phenylpentanenitrile 
• 631-61-8 ammonium acetate 
• 67-66-3 chloroform 
• 7726-95-6 bromine 
• 626-05-1 2,6-Dibromopyridine 
• 117068-71-0 2-(benzyloxy)-6-bromopyridine 
• 1644057-98-6 C₂₄H₃₇NOSn 
• 37746-78-4 4-bromo-trans-crotonic acid ethyl ester 
• 100-47-0 benzonitrile 
• 1644057-93-1 C₁₈H₁₅NO 
• 35070-08-7 2-methoxy-6-phenylpyridine 
• 108-86-1 bromobenzene 
• 164014-94-2 2-methoxy-6-(tri-n-butylstannyl)pyridine 

Downstream Products

• 13382-54-2 2-chloro-6-phenyl-pyridine 
• 1423231-35-9 2-phenoxy-6-phenylpyridine 
• 1810074-59-9 C₁₁H₁₅NO₂*ClH 
• 41419-25-4 6-phenylpiperidin-2-one 
• 39774-26-0 2-bromo-6-phenylpyridine 
• 337969-42-3 N-[(1S)-2-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-2-hydroxy-1-(methylethyl)ethyl]-2-(6-phenyl-2-pyridyloxy)acetamide 
• 88347-44-8 2-(6-phenyl-2-pyridyloxy)acetic acid 
• 337969-46-7 ethyl 2-(6-phenyl-2-pyridyloxy)acetate 
• 1008-89-5 2-phenylpyridine 

Relevant articles and documents

Rh(I)-Catalyzed Direct C6?H Arylation of 2-Pyridones with Aryl Carboxylic Acids

A Rh(I)-catalyzed C6-selective C?H arylation of 2-pyridones with inexpensive, readily available, safe and structurally diverse aryl carboxylic acids with the aid of a pyridine directing group is developed. This decarbonylative arylation protocol features an easy-to-handle catalytic system, and is amenable to diversely substituted 2-pyridones and aryl carboxylic acids. It allows access to a wide range of C6-arylated 2-pyridones, including those that are difficult to prepare using conventional C?H arylation processes. The method tolerates various electron-neutral, electron-rich and electron-deficient functional groups, and affords the products in 41–91% yields. (Figure presented.).

Vinylogous Blaise Reaction: Conceptually New Synthesis of Pyridin-2-ones

A conceptually new synthesis of pyridine rings by a [C 4 + CN] assembly has been developed by applying a vinylogous version of the classic Blaise reaction. The zinc-mediated reaction of (het)aryl or alkyl nitriles with ethyl-4-bromocrotonate pr