911372-80-0

Usage

Uses

Used in Research Applications:
(S)-4-(1-Aminoethyl)benzonitrile HCl is used as a research chemical for studying its properties and potential applications in various scientific fields. Its unique structure and reactivity make it a valuable compound for exploring new chemical reactions and syntheses.
Used in Chemical Industry:
In the chemical industry, (S)-4-(1-Aminoethyl)benzonitrile HCl is used as an intermediate in the synthesis of various organic compounds and pharmaceuticals. Its presence in the benzonitrile class allows it to participate in a wide range of chemical reactions, contributing to the production of diverse chemical products.
Used in Pharmaceutical Industry:
(S)-4-(1-Aminoethyl)benzonitrile HCl is used as a building block in the development of pharmaceutical compounds. Its unique structure and functional groups can be incorporated into drug molecules to enhance their therapeutic properties or improve their pharmacokinetic profiles.
Used in Drug Synthesis:
(S)-4-(1-Aminoethyl)benzonitrile HCl is used as a key component in the synthesis of certain drugs, where its specific chemical properties can be leveraged to create novel therapeutic agents with improved efficacy and safety profiles.
Used in Analytical Chemistry:
(S)-4-(1-Aminoethyl)benzonitrile HCl can be employed as a reagent or standard in analytical chemistry for the identification, quantification, or characterization of other compounds. Its distinct chemical properties make it suitable for use in various analytical techniques, such as chromatography, spectroscopy, or electrochemistry.

Upstream product

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• 911372-47-9 (R_S)-N-(1-(4-cyanophenyl)ethylidene)-2-methylpropane-2-sulfinamide 
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• 911372-65-1 (R_S)-N-((S)-1-(4-cyanophenyl)ethyl)-2-methylpropane-2-sulfinamide 
• 475106-59-3 (R,E)-N-[(4-cyanophenyl)methylene]-2-methyl-2-propanesulfinamide 
• 105-07-7 4-cyanobenzaldehyde 
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Relevant academic research and scientific papers

ANTIBODY-CONJUGATED CHEMICAL INDUCERS OF DEGRADATION OF BRM AND METHODS THEREOF

The subject matter described herein is directed to antibody-CIDE conjugates (Ab-CIDEs) that target BRM for degradation, to pharmaceutical compositions containing them, and to their use in treating diseases and conditions where BRM degradation is beneficial.

3-AZABICYCLO(3.1.0)HEXANE DERIVATIVES HAVING KDM5 INHIBITORY ACTIVITY AND USE THEREOF

The present invention provides KDM5 inhibitor. The compound disclosed herein represented by the general formula (I) : wherein all symbols have the same meanings as the definitions described in the specification; or a salt thereof is useful as a prophylact

Synthesis of α-Substituted Primary Benzylamines through Copper-Catalyzed Cross-Dehydrogenative Coupling

A copper-catalyzed route to α-substituted, primary benzylamines by C-H functionalization of alkylarenes is described. The method directly affords the amine hydrochloride salt. Catalyst loadings down to 0.1 mol % in combination with scalability, insensitivity to air and moisture, and no need for column chromatography makes the procedure highly practical. The facile synthesis of the racemate of a blockbuster drug highlights the relevance for the development of pharmaceuticals. Preliminary mechanistic data are also included.

MODULATORS OF ESTROGEN RECEPTOR PROTEOLYSIS AND ASSOCIATED METHODS OF USE

The present disclosure relates to bifunctional compounds, which find utility as modulators of estrogen receptor (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a cereblon, Von Hippel-Lindau ligase-binding moiety, Inhibitors of Apotosis Proteins, or mouse double-minute homolog 2 ligand, which binds to the respective E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

PYRROLOPYRIMIDIN-7-ONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS

Compounds of formula (I) or pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4, and R5 and are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Reversal of diastereofacial selectivity in hydride reductions of N-tert-butanesulfinyl imines

A variety of N-tert-butanesulfinyl imines were reduced with NaBH 4 in THF containing 2% water to provide the corresponding secondary sulfinamides in high yield and diastereoselectivity. By using the same sulfinyl imine starting materials and changing the reductant to L-Selectride, the stereoselectivity could be efficiently reversed to afford the opposite product diastereomer in high yield and selectivity.