91189-59-2

Basic information

• Product Name: Felodipine 3,5-DiMethyl Ester
• Synonyms: Felodipine 3,5-DiMethyl Ester;4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-diMethyl-3,5-pyridinedicarboxylic Acid 3,5-DiMethyl Ester;Clevidipine Butyrate iMpurity Ⅲ;diMethyl 4-(2',3'-dichlorophenyl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylate;Felodipine IMpurity B;4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid dimethyl ester;Cleviprex Impurity B;Felodipine Related Compound B
• CAS NO: 91189-59-2
• Molecular Formula: C₁₇H₁₇Cl₂NO₄
• Molecular Weight: 370.22718
• Product Categories: Aromatics;Dihydropyridine;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Clevidipine Butyrate impurity
• Mol File: 91189-59-2.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Felodipine 3,5-DiMethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: Felodipine 3,5-DiMethyl Ester(91189-59-2)
• EPA Substance Registry System: Felodipine 3,5-DiMethyl Ester(91189-59-2)

Safety Data

• Hazardous Substances Data: 91189-59-2(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 91189-59-2 differently. You can refer to the following data:
1. Dimethyl ester analogue of the calcium channel blockers Felopidine (F232375) and Nifedipine (N457000).
2. Felodipine 3,5-Dimethyl Ester (Felodipine EP Impurity B) is the dimethyl ester analogue of the calcium channel blockers Felopidine (F232375) and Nifedipine (N457000).

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 6334-18-5 2,3-dichlorobenzylaldehyde 
• 14205-39-1 methyl 3-aminocrotonate 
• 1215080-66-2 (R)-3-ethyl 5-((R)-1-hydroxy-3-(phenylthio)propan-2-yl) 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 124-41-4 sodium methylate 

Downstream Products

• 123853-39-4 (+)-4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-3-pyridinecarboxylic acid 

Relevant articles and documents

Compound and its as L-type calcium channel blocker or/and application of acetylcholine esterase inhibitors

Disclosed in this invention are compounds and the uses as L-type calcium channel blocker and/or acetylcholinesterase inhibitor thereof. The uses of said compounds in the manufactures of a medicament for the treatment of cardiovascular diseases, apoplexy or senile dementia are also disclosed in the present invention.

Facile and green synthesis of 1,4-dihydropyridine derivatives in n-butyl pyridinium tetrafluoroborate

l,4-Dihydropyridine derivatives were synthesized from the one-pot condensation of aldehydes, acetoacetates, and ammonium acetate in room-temperature ionic liquid n-butyl pyridinium tetrafluoroborate ([BPy][BF4]). Compared with classical Hantzsch reaction conditions, this new method has the advantage of excellent yields, short reaction time, and easy workup. The recovered ionic liquid could be recycled for at least five runs without losing its activity. Taylor & Francis Group, LLC.