Dimethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:Dimethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:91189-59-2
Molecular Formula:C17H17Cl2NO4
Molecular Weight:370.232
Hs Code.:
European Community (EC) Number:641-890-6
UNII:6LQ9G5T4HP
DSSTox Substance ID:DTXSID80391948
Nikkaji Number:J600.714G
ChEMBL ID:CHEMBL68394
Mol file:91189-59-2.mol

Synonyms:91189-59-2;Dimethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;Felodipine 3,5-Dimethyl Ester;4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester;3,5-dimethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;CHEMBL68394;SCHEMBL3067467;DTXSID80391948;AMY23323;BCP18280;AKOS024423532;AS-74574;Felodipine Impurity B;Clevidipine Impurity 3;FT-0668477;F19233;A900095;EN300-18115676;H-161/33;Z657350588;2,6-dimethyl-3,5-dicarbomethoxy-4-(2',3'-dichlorophenyl)-1,4-dihydropyridine;dimethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate;Dimethyl4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylic acid dimethylester;Clevidipine Butyrate iMpurity;diMethyl 4-(2',3'-dichlorophenyl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylate

Suppliers and Price of Dimethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Felodipine3,5-DimethylEster
100mg
$ 185.00

Total 16 raw suppliers

Chemical Property of Dimethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property:

Melting Point:184-186°C
PSA：64.63000
LogP:3.90300
Storage Temp.:Amber Vial, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:369.0534634
Heavy Atom Count:24
Complexity:561

Purity/Quality:

99%, ^*data from raw suppliers

Felodipine3,5-DimethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(C(=C(N1)C)C(=O)OC)C2=C(C(=CC=C2)Cl)Cl)C(=O)OC
Uses Dimethyl ester analogue of the calcium channel blockers Felopidine (F232375) and Nifedipine (N457000). Felodipine 3,5-Dimethyl Ester (Felodipine EP Impurity B) is the dimethyl ester analogue of the calcium channel blockers Felopidine (F232375) and Nifedipine (N457000).

Technology Process of Dimethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 7 articles about Dimethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 105-45-3
acetoacetic acid methyl ester

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 91189-59-2
4-(-2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl ester

Guidance literature:: With ammonium acetate; N-butylpyridinium tetrafluoroborate; at 100 - 110 ℃; for 3h;
DOI:10.1080/00397911.2010.525773

Reference yield: 82.1%

: 105-45-3
acetoacetic acid methyl ester

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 14205-39-1
methyl 3-aminocrotonate

: 91189-59-2
4-(-2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl ester

Guidance literature:: In methanol; at 60 ℃; for 10h; Temperature; Solvent;

Reference yield: 66.0%

: ethyl aminocrotonate

: 105-45-3
acetoacetic acid methyl ester

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 72509-76-3,86189-69-7
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate

: 91189-59-2
4-(-2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl ester

: 79925-38-5
4-(2,3-dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

Guidance literature:: acetoacetic acid methyl ester; 2,3-dichlorobenzylaldehyde; piperidine; 2-Picolinic acid; In isopropyl alcohol; at 40 - 45 ℃; for 6h;

ethyl aminocrotonate; In isopropyl alcohol; for 4h; Heating / reflux;