91246-63-8Relevant academic research and scientific papers
Structural optimization of diphenylpyrimidine derivatives (DPPYs) as potent Bruton's tyrosine kinase (BTK) inhibitors with improved activity toward B leukemia cell lines
Zhao, Dan,Huang, Shanshan,Qu, Menghua,Wang, Changyuan,Liu, Zhihao,Li, Zhen,Peng, Jinyong,Liu, Kexin,Li, Yanxia,Ma, Xiaodong,Shu, Xiaohong
, p. 444 - 455 (2016/12/06)
A new series of diphenylpyrimidine derivatives (DPPYs) bearing various aniline side chains at the C-2 position of pyrimidine core were synthesized as potent BTK inhibitors. Most of these inhibitors displayed improved activity against B leukemia cell lines compared with lead compound spebrutinib. Subsequent studies showed that the peculiar inhibitor 7j, with IC50values of 10.5 μM against Ramos cells and 19.1 μM against Raji cells, also displayed slightly higher inhibitory ability than the novel agent ibrutinib. Moreover, compound 7j is not sensitive to normal cells PBMC, indicating low cell cytotoxicity. In addition, flow cytometry analysis indicated that 7j significantly induced the apoptosis of Ramos cells, and arrested the cell cycle at the G0/G1 phase. These explorations provided new clues to discover pyrimidine scaffold as more effective BTK inhibitors.
Organosoluble copper clusters as precatalysts for carbon - Heteroelement bond-forming reactions: Microwave and conventional heating
Manbeck, Gerald F.,Lipman, Adam J.,Stockland Jr., Robert A.,Freidl, Adrienne L.,Hasler, Amy F.,Stone, Joshua J.,Guzei, Ilia A.
, p. 244 - 250 (2007/10/03)
(Chemical Equation Presented). The coupling of aryl iodides with alcohols under mild conditions has been explored using self-assembled octanuclear copper clusters as catalysts. Reactions involving tetrahydrofurfuryl alcohol were typically complete in 4-8
