91246-71-8

Upstream product

• 104-94-9 4-methoxy-aniline 
• 78-94-4 methyl vinyl ketone 
• 22094-69-5 N-(4-methoxyphenyl)glycine 
• 67-64-1 acetone 
• 50-00-0 formaldehyd 
• 116-11-0 2-Methoxypropene 
• 3299-38-5 4-(diethylamino)butan-2-one 
• 100129-40-6 N-(3-chloro-but-2-enyl)-p-anisidine 

Downstream Products

• 872515-58-7 N-(4-methoxyphenyl)-N-(3-oxobutyl)-(E)-but-2-enamide 
• 872515-52-1 N-(4-methoxyphenyl)-N-(3-oxobutyl)propenamide 
• 1032607-22-9 N-(4-methoxyphenyl)-N-(3-oxobutyl)-3-phenylpropynamide 
• 1032606-11-3 N-(4-methoxyphenyl)-N-(3-oxobutyl)-(E)-2-methylbut-2-enamide 
• 1032605-77-8 N-(4-methoxyphenyl)-N-(3-oxobutyl)-(E)-3-(furan-2-yl)propenamide 
• 1032606-08-8 N-(4-methoxyphenyl)-N-(3-oxobutyl)-2-methylpropenamide 

Relevant academic research and scientific papers

Cobalt-Porphyrin-Catalyzed Intramolecular Buchner Reaction and Arene Cyclopropanation of In Situ Generated Alkyl Diazomethanes

Cobalt(II)-porphyrin catalyzed intramolecular Buchner reaction and arene cyclopropanation of alkyl diazomethanes generated in situ from N-tosylhydrazones gave a range of bicyclic cycloheptatriene fused pyrrolidines and tetracyclic cyclopropane fused pyrro

Amphiphilic methyleneamino synthon through organic dye catalyzed- decarboxylative aminoalkylation

The utilization of a photo-induced synthon generated from N-phenyl glycine by an organic dye and visible light irradiation is disclosed. The intermediate could be coupled with either a radical or a nucleophile in a simple operation to afford several natural product-like compounds.

Lithium tetrafluoroborate catalyzed highly efficient inter- and intramolecular aza-Michael addition with aromatic amines

Lithium tetrafluoroborate has been demonstrated for the first time to be an efficient catalyst in intermolecular aza-Michael addition aromatic amines to electron deficient alkenes. Suitability of the same catalyst in intramolecular aza-Michael addition leading 2-aryl-2,3-dihydroquinolin-4(1H) ones has also been described.

"On-water" conjugate additions of anilines

The conjugate addition of anilines onto unsaturated ketones, esters and N-acylpyrroles was investigated. Based on a recently proposed explanation for the phenomenon of on-water catalysis, operationally simple and mild reaction conditions for effecting these addition reactions have been developed. The success of these additions provides further support for the acid-catalysed nature of on-water chemistry.

Zirconium tetrakis(dodecylsulfate) as an efficient and recyclable lewis acid-surfactant-combined catalyzed C-C and C-N bond forming under mild and environmentally benign conditions

A green catalytic method for C-C and C-N bond forming via Michael addition of aromatic amines and indoles to electron-deficient olefins using Zirconium tetrakis(dodecylsulfate) in water under mild conditions with high yields and selectivity has been developed. The reusability of the catalyst has been successfully examined without any noticeable loss of its catalytic activity.

Solvent-promoted and -controlled Aza-Michael reaction with aromatic amines

(Chemical Equation Presented) 1,4-Addition of anilines onto Michael acceptors proceeds easily in specific polar protic solvents, without any promoting agent. According to the solvent and to the electrophile, the selectivity of the reaction can be finely tuned. With methyl acrylate as electrophile, only monoaddition takes place in water, while the diadduct is yielded in hexafluoroisopropyl alcohol (HFIP). The use of methyl vinyl ketone as a partner affords the monoadduct in water, the diadduct in trifluoroethanol (TFE), and the quinoline in HFIP.

[HP(HNCH2CH2)3N]NO3: An efficient homogeneous and solid-supported promoter for aza and thia-Michael reactions and for Strecker reactions

In the presence of a catalytic amount of an azaphosphatrane nitrate salt, amines and thiols react readily with Michael acceptors. The salt is also an efficient promoter for the one pot synthesis of α-amino and α-amidonitriles. By anchoring the salt to Merrifield Resin, a reusable heterogeneous catalyst is obtained for these reactions. Evidence is presented for catalysis being attributable solely to the NO3- ion.

Diastereoselective synthesis of 4-hydroxypiperidin-2-ones via Cu(I)-catalyzed reductive aldol cyclization

(Chemical Equation Presented) 4-Hydroxypiperidin-2-ones may be prepared in highly diastereoselective fashion using a Cu(I)-catalyzed reductive aldol cyclization of αβ-unsaturated amides with ketones. Used in combination with proline-catalyzed asymmetric M

Rare Earth Metal Complexes as Water-Tolerant Lewis Acid Catalysts in Organic Synthesis

Rare earth metal triflates are stable in aqueous media and can act as Lewis acid catalysts in several carbon-carbon bond forming reactions. This article describes some of these reactions; aldol and Mannich-type reactions in aqueous solution, and Friedel-Crafts acylations and Fries rearrangement in organic solvents. The reactions proceeded smoothly in the presence of a catalytic amount of the triflate under mild conditions. Moreover, the catalysts could be recovered after the reactions were completed and could be reused.

A Novel Mannich-type Reaction in Aqueous Media. Lanthanide Triflate-catalysed Condensation of Aldehydes, Amines and Vinyl Ethers for the Synthesis of β-Amino Ketones

A novel Mannich-type reation between an aldehyde, an amine and a vinyl ether is catalysed by lanthanide triflates to afford a β-amino ketone in good yield in aqueous media.