91375-44-9Relevant academic research and scientific papers
Inhibitors of protein farnesyltransferase and squalene synthase
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, (2008/06/13)
The present invention provides a compound of the formula STR1 or a pharmaceutically acceptable salt thereof, which are useful in inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.
Silylamines in Organic Synthesis. Facile Synthetic Routes to Unsaturated Protected Primary Amines.
Corriu, Robert J. P.,Huynh, Vilam,Iqbal, Javed,Moreau, Joel J. E.,Vernhet, Claude
, p. 6231 - 6244 (2007/10/02)
The reactions of lithium N,N-bis(trimethylsilyl)aminomethyl acetylide with electrophilic reagents offered a short preparation of substituted and functional propargyl amines.These are shown to be useful precursors of various saturated protected primary amines.Addition reactions to the carbon-carbon triple bond or isomerisation reactions gave rise to allylic, dienic and α-allenic amines. Keywords: Silylamines; propargylamines, α-allenylamines; N,N-bis(silyl)dienamines.
USES OF Si-N BONDS IN ORGANIC SYNTHESIS. A DIRECT SYNTHESIS OF FUNCTIONAL PROTECTED PROPARGYLIC PRIMARY AMINES.
Corriu, Robert J. P.,Huynh, Vilam,Moreau, Joel J. E.
, p. 1887 - 1890 (2007/10/02)
An easy route to lithium N,N-bis(trimethylsilyl)aminomethylacetylide 1 is described.Reactions of 1 with electrophiles give rise to various protected primary amines.
