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Usage

Uses

Used in Pharmaceutical Industry:
DepropylaMino Hydroxy Propafenone is used as a metabolite of the sodium channel blocker Propafenone (P757500) for understanding the metabolic pathways and pharmacokinetics of the parent drug. This information is crucial for assessing the safety, efficacy, and dosing regimens of Propafenone in treating abnormal heart rhythms.
Additionally, the study of DepropylaMino Hydroxy Propafenone can aid in the development of new drugs with improved pharmacological properties or reduced side effects, by providing insights into the metabolic transformations that occur in the body.

Upstream product

• 22525-95-7 1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one 
• 189766-45-8 2-(2-phenethyl-1,3-dioxolan-2-yl)phenol 
• 3516-95-8 2'-hydroxy-3-phenylpropiophenone 
• 189766-46-9 (S)-2,2-dimethyl-4-{2-[2-(2-phenylethyl)-1,3-dioxolan-2-yl]phenoxymethyl}-1,3-dioxolane 
• 100-52-7 benzaldehyde 
• 118-93-4 o-hydroxyacetophenone 

Relevant academic research and scientific papers

Improved Synthesis of the Enantiomers of Propafenone Using Chiral Building Blocks

A short and efficient synthesis of the enantiomers of the antiarrhythmic drug propafenone (1) is described using both (R)-isopropylideneglycerol tosylate and (S)-glycidyl tosylate as chiral building blocks. The key step of the high yield synthesis is the

Studies on the metabolism of propafenone. 1st comm.: Synthesis and chromatographic/mass spectrometric properties of the labelled compound and of the reference substances

The synthesis of 14C-propafenone and 2H-propafenone (propafenone: 2-(2'-hydroxy-3'-propylamino-propoxy)-ω-phenyl-propiophenone hydrochloride) and some reference compounds is described. The thin-layer chromatographic, high-performance liquid and gas chromatographic properties of the substances are described. Propafenone and the reference substances were studied by mass spectrometry and compared with each other, with respect to structural elucidation of the metabolites. The chromatographic and mass spectrometric data (key ions) enables the metabolites of propafenone to be identified in biological material.